Detection and clinical surveillance of laryngeal cancer by serum lipid associated sialic acid (LASA) test

L. Santamaria, G. B. Galioto, M. Benazzo

Research output: Contribution to journalArticle

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Abstract

Lipid associated sialic acid (LASA) test was proved to be a broad spectrum marker for the diagnosis of both epithelial an mesenchimal malignancies. The present work was focused on the reliability of such test for the early diagnosis and clinical monitoring of laryngeal cancers. In this regard 100 healthy persons (controls) and 150 pts. with laryngeal carcinomas were submitted to LASA test, according to Katopodis et al. All cancers showed a positive correlation with abnormal concentration of LASA (>19 mg/100 ml) with specificity = 100% (no false positives, excluding acute flogosis conditions and acute rheumatoid arthritis) and sensitivity = 96% (few false negatives). LASA was found to be relevant for clinical monitoring after laringectomy; indeed, LASA was successfully adopted to detect postoperative recurrencies or lymphnode metastases in one third (50/150) of cases. LASA negative lymphnode metachronous enlargements (15/150 cases) turned out to be also histologically negative for malignancy.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalJournal of Tumor Marker Oncology
Volume2
Issue number1
Publication statusPublished - 1987

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Laryngeal Neoplasms
Serum
Neoplasms
lipid-associated sialic acid
Early Diagnosis
Rheumatoid Arthritis
Neoplasm Metastasis
Carcinoma

ASJC Scopus subject areas

  • Cancer Research

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Detection and clinical surveillance of laryngeal cancer by serum lipid associated sialic acid (LASA) test. / Santamaria, L.; Galioto, G. B.; Benazzo, M.

In: Journal of Tumor Marker Oncology, Vol. 2, No. 1, 1987, p. 41-49.

Research output: Contribution to journalArticle

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