Lipid associated sialic acid (LASA) test was proved to be a broad spectrum marker for the diagnosis of both epithelial an mesenchimal malignancies. The present work was focused on the reliability of such test for the early diagnosis and clinical monitoring of laryngeal cancers. In this regard 100 healthy persons (controls) and 150 pts. with laryngeal carcinomas were submitted to LASA test, according to Katopodis et al. All cancers showed a positive correlation with abnormal concentration of LASA (>19 mg/100 ml) with specificity = 100% (no false positives, excluding acute flogosis conditions and acute rheumatoid arthritis) and sensitivity = 96% (few false negatives). LASA was found to be relevant for clinical monitoring after laringectomy; indeed, LASA was successfully adopted to detect postoperative recurrencies or lymphnode metastases in one third (50/150) of cases. LASA negative lymphnode metachronous enlargements (15/150 cases) turned out to be also histologically negative for malignancy.
|Number of pages||9|
|Journal||Journal of Tumor Marker Oncology|
|Publication status||Published - 1987|
ASJC Scopus subject areas
- Cancer Research