Detection and localization of surgically resectable cancers with a multi-analyte blood test

JD Cohen, L Li, Y Wang, C Thoburn, B Afsari, L Danilova, C Douville, AA Javed, F Wong, A Mattox, RH Hruban, CL Wolfgang, MG Goggins, MD Molin, TL Wang, R Roden, AP Klein, J Ptak, L Dobbyn, J SchaeferN Silliman, M Popoli, JT Vogelstein, JD Browne, RE Schoen, RE Brand, J Tie, P Gibbs, HL Wong, AS Mansfield, J Jen, SM Hanash, M Falconi, PJ Allen, S Zhou, C Bettegowda, LA Diaz, C Tomasetti, KW Kinzler, B Vogelstein, AM Lennon, N Papadopoulos

Research output: Contribution to journalArticle

Abstract

Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients. © 2017 The Authors.
Original languageEnglish
Pages (from-to)926-930
Number of pages5
JournalScience
Volume359
Issue number6378
DOIs
Publication statusPublished - 2018

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Hematologic Tests
Liver Neoplasms
Ovarian Neoplasms
Esophagus
Pancreas
Neoplasms
Stomach
Breast
Lung
Mutation
DNA
Proteins

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Cohen, JD., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L., ... Papadopoulos, N. (2018). Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science, 359(6378), 926-930. https://doi.org/10.1126/science.aar3247

Detection and localization of surgically resectable cancers with a multi-analyte blood test. / Cohen, JD; Li, L; Wang, Y; Thoburn, C; Afsari, B; Danilova, L; Douville, C; Javed, AA; Wong, F; Mattox, A; Hruban, RH; Wolfgang, CL; Goggins, MG; Molin, MD; Wang, TL; Roden, R; Klein, AP; Ptak, J; Dobbyn, L; Schaefer, J; Silliman, N; Popoli, M; Vogelstein, JT; Browne, JD; Schoen, RE; Brand, RE; Tie, J; Gibbs, P; Wong, HL; Mansfield, AS; Jen, J; Hanash, SM; Falconi, M; Allen, PJ; Zhou, S; Bettegowda, C; Diaz, LA; Tomasetti, C; Kinzler, KW; Vogelstein, B; Lennon, AM; Papadopoulos, N.

In: Science, Vol. 359, No. 6378, 2018, p. 926-930.

Research output: Contribution to journalArticle

Cohen, JD, Li, L, Wang, Y, Thoburn, C, Afsari, B, Danilova, L, Douville, C, Javed, AA, Wong, F, Mattox, A, Hruban, RH, Wolfgang, CL, Goggins, MG, Molin, MD, Wang, TL, Roden, R, Klein, AP, Ptak, J, Dobbyn, L, Schaefer, J, Silliman, N, Popoli, M, Vogelstein, JT, Browne, JD, Schoen, RE, Brand, RE, Tie, J, Gibbs, P, Wong, HL, Mansfield, AS, Jen, J, Hanash, SM, Falconi, M, Allen, PJ, Zhou, S, Bettegowda, C, Diaz, LA, Tomasetti, C, Kinzler, KW, Vogelstein, B, Lennon, AM & Papadopoulos, N 2018, 'Detection and localization of surgically resectable cancers with a multi-analyte blood test', Science, vol. 359, no. 6378, pp. 926-930. https://doi.org/10.1126/science.aar3247
Cohen, JD ; Li, L ; Wang, Y ; Thoburn, C ; Afsari, B ; Danilova, L ; Douville, C ; Javed, AA ; Wong, F ; Mattox, A ; Hruban, RH ; Wolfgang, CL ; Goggins, MG ; Molin, MD ; Wang, TL ; Roden, R ; Klein, AP ; Ptak, J ; Dobbyn, L ; Schaefer, J ; Silliman, N ; Popoli, M ; Vogelstein, JT ; Browne, JD ; Schoen, RE ; Brand, RE ; Tie, J ; Gibbs, P ; Wong, HL ; Mansfield, AS ; Jen, J ; Hanash, SM ; Falconi, M ; Allen, PJ ; Zhou, S ; Bettegowda, C ; Diaz, LA ; Tomasetti, C ; Kinzler, KW ; Vogelstein, B ; Lennon, AM ; Papadopoulos, N. / Detection and localization of surgically resectable cancers with a multi-analyte blood test. In: Science. 2018 ; Vol. 359, No. 6378. pp. 926-930.
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AU - Danilova, L

AU - Douville, C

AU - Javed, AA

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AU - Goggins, MG

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AU - Ptak, J

AU - Dobbyn, L

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AU - Vogelstein, JT

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AU - Allen, PJ

AU - Zhou, S

AU - Bettegowda, C

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