Detection and management of early stage inflammatory bowel disease: an update for clinicians

Laura Loy, Giulia Roda, Gionata Fiorino, Mariangela Allocca, Federica Furfaro, Marjorie Argollo, Laurent Peyrin-Biroulet, Silvio Danese

Research output: Contribution to journalReview articlepeer-review


INTRODUCTION: Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, are lifetime chronic and progressive disorders of poorly known etiology. Over the past few decades, new therapeutic approaches, including early and more aggressive intervention with immunomodulators and biological agents have offered the possibility of a favorable modification in the natural history of inflammatory bowel diseases. Area covered: Here, we review the literature about the effectiveness of early detection and intervention in adult inflammatory bowel diseases patients. Expert commentary: Detecting and managing early stages of inflammatory bowel diseases represents an effective strategy to avoid disease progression in selected patients. Primary care physicians may play a key role in attaining these outcomes by recognizing the signs and symptoms early and making timely referrals. Moreover, early therapeutic intervention with complete disease control may allow dose reduction or even treatment withdrawal in the maintenance phase, reducing side effects, costs, and also improving quality of life.

Original languageEnglish
Pages (from-to)547-555
Number of pages9
JournalExpert Review of Gastroenterology and Hepatology
Issue number6
Publication statusPublished - Jun 2019


  • Anti-Inflammatory Agents/adverse effects
  • Colitis, Ulcerative/diagnosis
  • Crohn Disease/diagnosis
  • Early Diagnosis
  • Gastrointestinal Agents/adverse effects
  • Humans
  • Predictive Value of Tests
  • Treatment Outcome


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