Detection and quantification of EBV, HHV-6 and CMV DNA in the gastrointestinal tract of HIV-positive patients

F. Falasca, P. Maida, A. Gaeta, S. Verzaro, I. Mezzaroma, A. Fantauzzi, G. Donato, E. Bonci, C. Castilletti, G. Antonelli, O. Turriziani

Research output: Contribution to journalArticlepeer-review

Abstract

Human herpes viruses (HHVs) have been frequently detected in the gastrointestinal (GI) tract and may contribute to the development of gastric cancer. In the present study, the detection rate and viral load of Epstein Barr virus (EBV), HHV-6 and Cytomegalovirus (CMV) were assessed in the GI tract of human immunodeficiency virus (HIV) positive patients and of uninfected patients. The analysis revealed a significantly higher detection rate of EBV and HHV-6 in HIV-infected individuals than in uninfected subjects (88.5 vs 63 %; p = 0.03). Moreover, EBV DNA load was significantly higher in the stomach of HIV patients than in controls. These data suggest that the HIV infection status may increase the persistence of these viruses in the GI compartment. Intriguingly, CMV DNA was undetectable in all biopsy specimens analyzed.

Original languageEnglish
Pages (from-to)1033-1037
Number of pages5
JournalInfection
Volume42
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • CMV
  • EBV
  • Gastrointestinal apparatus
  • HHV-6
  • HIV-1

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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