Detection and quantification of mammaglobin in the blood of breast cancer patients: Can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study

G. Gargano, V. Agnese, V. Calò, S. Corsale, C. Augello, L. Bruno, L. La Paglia, A. Gullo, L. Ottini, A. Russo, F. Fulfaro, G. Rinaldi, A. Crosta, G. Cicero, O. Majorana, L. Palmeri, C. Cipolla, A. Agrusa, G. Gulotta, V. MorelloG. Di Fede, V. Adamo, G. Colucci, R. M. Tomasino, M. R. Valerio, V. Bazan, Antonio Russo

Research output: Contribution to journalArticle

Abstract

Background: Mammaglobin is expressed mainly in mammary tissue, overexpressed in breast cancer (BC) and rarely in other tissue. The aim of this study was to assess the sensitivity and specificity of transcript MGB1 detection and to evaluate the role of MGB1 as potential clinical marker for the detection of disseminated cancer cells in the blood of BC patients. Patients and methods: A consecutive series of 23 BC tissues, 36 peripheral blood BC samples and 35 healthy peripheral blood samples was prospectively recruited to investigate MGB1 expression by means of a quantitative Real Time RT-PCR assay. Results: MGB1 overexpression in tissue samples of BC patients is significantly associated only with high level of Ki67 (P

Original languageEnglish
JournalAnnals of Oncology
Volume17
Issue numberSUPPL. 7
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Breast cancer
  • Disseminated cancer cells
  • Mammaglobin (MGB1)
  • Real time RT-PCR

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Gargano, G., Agnese, V., Calò, V., Corsale, S., Augello, C., Bruno, L., La Paglia, L., Gullo, A., Ottini, L., Russo, A., Fulfaro, F., Rinaldi, G., Crosta, A., Cicero, G., Majorana, O., Palmeri, L., Cipolla, C., Agrusa, A., Gulotta, G., ... Russo, A. (2006). Detection and quantification of mammaglobin in the blood of breast cancer patients: Can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. Annals of Oncology, 17(SUPPL. 7). https://doi.org/10.1093/annonc/mdl948