Detection in human cells of alkylated macromolecules attributable to exposure to nitrosamines.

R. Montesano, H. Brésil, P. Degan, G. Martel-Planche, M. Serres, C. P. Wild

Research output: Contribution to journalArticlepeer-review

Abstract

Various methods for detecting DNA alkylation adducts are described briefly, with emphasis on immunoassays using antibodies against O6-methyldeoxyguanosine (O6-medGua), O4-methylthymidine (O4-meThy) and 7-methyldeoxyguanosine (7-medGua). The application of these methods to epidemiological studies is discussed, and results obtained so far on the presence of DNA alkylation adducts in human tissues are presented.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalIARC scientific publications
Issue number89
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Medicine(all)

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