Detection of β-nerve growth factor mRNA in the human fetal brain

Antonio Pizzuti, Giuseppe Borsani, Andrea Falini, Elena I. Rugarli, Alessandro Sidoli, Francisco E. Baralle, Guglielmo Scarlato, Vincenzo Silani

Research output: Contribution to journalArticlepeer-review

Abstract

Nerve growth factor (NGF) is a trophic molecule recently demonstrated to interact with different structures in the central nervous system. The expression of the β-NGF mRNA from human fetal cortices at the 15-16th week of gestational age has been demonstrated and quantitated by polymerase chain reaction amplification of the specific cDNA. β-NGF mRNA expression in the human brain coincides with the period of active differentiation and synaptogenesis, suggesting that the trophic agent plays a role in the cerebral development.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalBrain Research
Volume518
Issue number1-2
DOIs
Publication statusPublished - Jun 4 1990

Keywords

  • Human fetal brain
  • Nerve growth factor
  • Polymerase chain reaction
  • β-Nerve growth factor mRNA

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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