Detection of an unstable non-coding tandem repeat in the ZNF291 gene

Vallo Laura, Bonifazi Emanuela, Angelini Corrado, Novelli Giuseppe, Botta Annalisa

Research output: Contribution to journalArticle

Abstract

Repeat instability is an important form of mutation that is responsible for several neurological, neurodegenerative and neuromuscular disorders. In this study we identified an unstable [CCTG]n repeat in the second intron of the ZNF291 gene, on chromosome 15q21-24. The repeat number is polymorphic in normal population and the ZNF291 transcript is expressed in different areas of human brain, skeletal muscle and heart. These findings suggest that ZNF291 gene should be taken in consideration as an attractive candidate for neuromuscular expansion related diseases mapping in this locus.

Original languageEnglish
Pages (from-to)405-407
Number of pages3
JournalMolecular and Cellular Probes
Volume21
Issue number5-6
DOIs
Publication statusPublished - Oct 2007

Keywords

  • Candidate gene
  • Expansion disease
  • Repeat instability

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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    Laura, V., Emanuela, B., Corrado, A., Giuseppe, N., & Annalisa, B. (2007). Detection of an unstable non-coding tandem repeat in the ZNF291 gene. Molecular and Cellular Probes, 21(5-6), 405-407. https://doi.org/10.1016/j.mcp.2007.04.001