Detection of aneuploid cells in fibroblast cultures from the father of two trisomy 21 patients

G. Simoni; A. Mottura; M. Stefanini; L. Larizza; P. Maraschio; F. Nuzzo

Detection of aneuploid cells in fibroblast cultures from the father of two trisomy 21 patients

G. Simoni, A. Mottura, M. Stefanini, L. Larizza, P. Maraschio, F. Nuzzo

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Chromosome analysis was performed on successive cultures of fibroblasts from the parents of two trisomic 21 patients. Starting from the 7th passage in the father cultures an aneuploid clone showing an extra E like chromosome was found, which eventually overgrew the cell population. The significance of this cytogenetic finding is discussed in relation to the recurrence of the trisomy in the family.

Original language	English
Pages (from-to)	169-171
Number of pages	3
Journal	Annales de Genetique
Volume	19
Issue number	3
Publication status	Published - 1976

ASJC Scopus subject areas

Genetics

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title = "Detection of aneuploid cells in fibroblast cultures from the father of two trisomy 21 patients",

abstract = "Chromosome analysis was performed on successive cultures of fibroblasts from the parents of two trisomic 21 patients. Starting from the 7th passage in the father cultures an aneuploid clone showing an extra E like chromosome was found, which eventually overgrew the cell population. The significance of this cytogenetic finding is discussed in relation to the recurrence of the trisomy in the family.",

author = "G. Simoni and A. Mottura and M. Stefanini and L. Larizza and P. Maraschio and F. Nuzzo",

year = "1976",

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AU - Simoni, G.

AU - Mottura, A.

AU - Stefanini, M.

AU - Larizza, L.

AU - Maraschio, P.

AU - Nuzzo, F.

PY - 1976

Y1 - 1976

N2 - Chromosome analysis was performed on successive cultures of fibroblasts from the parents of two trisomic 21 patients. Starting from the 7th passage in the father cultures an aneuploid clone showing an extra E like chromosome was found, which eventually overgrew the cell population. The significance of this cytogenetic finding is discussed in relation to the recurrence of the trisomy in the family.

AB - Chromosome analysis was performed on successive cultures of fibroblasts from the parents of two trisomic 21 patients. Starting from the 7th passage in the father cultures an aneuploid clone showing an extra E like chromosome was found, which eventually overgrew the cell population. The significance of this cytogenetic finding is discussed in relation to the recurrence of the trisomy in the family.

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Detection of aneuploid cells in fibroblast cultures from the father of two trisomy 21 patients

Abstract

ASJC Scopus subject areas

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