Detection of basic Fibroblast Growth Factor mRNA in urinary bladder cancer: Correlation with local relapses

Paola Gazzaniga, Orietta Gandini, Angela Gradilone, Ida Silvestri, Laura Giuliani, Massimo Magnanti, Michele Gallucci, Gloria Saccani, Luigi Frati, Anna Maria Aglianò

Research output: Contribution to journalArticle

Abstract

Natural history of bladder cancer is characterized by high risk of disease progression even for patients with a clinical diagnosis of superficial disease; in these tumors, the occurrence of local relapse is known to be dependent on the angiogenesis rate. Basic fibroblast growth factor (bFGF), has been described to be elevated in urine and serum of patients with bladder cancer. We investigated the expression of bFGF at mRNA level in a panel of 32 transitional cell tumors of the urinary bladder and in normal bladder tissues used as controls. Expression of bFGF was found elevated in most tumors of high stage, where its presence was found correlated with the occurrence of early local relapses. Furthermore, bFGF was found highly expressed in the majority of tumors showing a high bcl-2 expression rate. Our data suggest that bFGF expression could contribute to the progression of disease; it may provide a prognostic indicator in the identification of patients with high risk for occurrence of local relapses.

Original languageEnglish
Pages (from-to)1123-1127
Number of pages5
JournalInternational Journal of Oncology
Volume14
Issue number6
Publication statusPublished - Jun 1999

Keywords

  • bFGF
  • Bladder cancer
  • Relapse

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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