Detection of calbindin-D immunoreactivity in human follicular dendritic cells

M. Chilosi, C. Doglioni, P. Pelosio, A. Mombello, L. Montagna, A. Benedetti, M. Lestani, P. Giovanni, F. Menestrina

Research output: Contribution to journalArticlepeer-review

Abstract

The calcium-binding protein calbindin-D (28 kD) has been analysed immunohistochemically in different human lymphoid tissues. Combined immunohistochemical staining showed that calbindin-D (28 kD) is expressed by only a proportion of dendritic cells within the light zone of germinal centres, where antigens in the form of immune complexes are trapped and presented to B lymphocytes. All other cell types including macrophages, interdigitating cells, and various lymphocyte populations were negative. The expression of calbindin-D in this functionally relevant subset of follicular dendritic cells could have a role in the regulation of proliferation and selection of memory B-cells by modulating the concentration of calcium ions. Calbindin-D may be a useful marker for analysing in situ the phases of follicular development in different physiological and pathological conditions.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalJournal of Pathology
Volume166
Issue number2
Publication statusPublished - 1992

Keywords

  • calbindin-D
  • follicular dendritic cells
  • immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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