Detection of corpus callosum malformations in pediatric population using the discriminative direction in multiple kernel learning

Denis Peruzzo, Filippo Arrigoni, Fabio Triulzi, Cecilia Parazzini, Umberto Castellani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper we propose a Multiple Kernel Learning (MKL) classifier to detect malformations of the Corpus Callosum (CC) and apply it in a pediatric population. Furthermore, we extend the concept of discriminative direction to the linear MKL methods, implementing it in a single subject analysis framework. The CC is characterized using different measures derived from Magnetic Resonance Imaging (MRI) data and the MKL approach is used to efficiently combine them. The discriminative direction analysis highlights those features that lead the classification for each given subject. In the case of a CC with malformation this means highlighting the abnormal characteristics of the CC that guide the diagnosis. Experiments show that the method correctly identifies the malformative aspects of the CC. Moreover, it is able to identify dishomogeneus, localized or widespread abnormalities among the different features. The proposed method is therefore suitable for supporting neuroradiologists in the decision-making process, providing them not only with a suggested diagnosis, but also with a description of the pathology.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PublisherSpringer Verlag
Pages300-307
Number of pages8
Volume8674 LNCS
EditionPART 2
ISBN (Print)9783319104690
DOIs
Publication statusPublished - 2014
Event17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - Boston, MA, United States
Duration: Sep 14 2014Sep 18 2014

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume8674 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014
CountryUnited States
CityBoston, MA
Period9/14/149/18/14

Keywords

  • brain imaging
  • computer-aided diagnosis
  • magnetic resonance imaging
  • multiple kernel learning

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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  • Cite this

    Peruzzo, D., Arrigoni, F., Triulzi, F., Parazzini, C., & Castellani, U. (2014). Detection of corpus callosum malformations in pediatric population using the discriminative direction in multiple kernel learning. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (PART 2 ed., Vol. 8674 LNCS, pp. 300-307). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 8674 LNCS, No. PART 2). Springer Verlag. https://doi.org/10.1007/978-3-319-10470-6_38