TY - JOUR
T1 - Detection of cytomegalovirus in saliva from infants undergoing sepsis evaluation in the neonatal intensive care unit
T2 - The VIRIoN-C study
AU - Ronchi, Andrea
AU - Ouellette, Christopher P.
AU - Mejías, Asuncion
AU - Salamon, Douglas
AU - Leber, Amy
AU - Pugni, Lorenza
AU - Mosca, Fabio
AU - Sánchez, Pablo J.
PY - 2019
Y1 - 2019
N2 - To determine the frequency of detection of cytomegalovirus (CMV) among infants evaluated for late-onset sepsis in the neonatal intensive care unit (NICU). This study was a prospective cohort study. During the 13-month study, 84 infants underwent 116 sepsis evaluations, and CMV DNA was detected in saliva in three (4%) infants (median: gestational age 28 weeks, birth weight 950 g), representing 5% (n=6) of all sepsis evaluations. One infant had CMV DNA detected in saliva in all four sepsis evaluations. Two infants had acquired CMV infection, while the timing of CMV acquisition could not be determined in one infant. Two of the three infants had concomitant Gram-negative bacteremia and urinary tract infections (UTIs), two developed severe bronchopulmonary dysplasia (BPD) and none died. Detection of CMV DNA in saliva occurred in 4% of infants and 5% of sepsis evaluations. Persistence of CMV DNA shedding in saliva made attribution of clinical illness difficult to ascertain.
AB - To determine the frequency of detection of cytomegalovirus (CMV) among infants evaluated for late-onset sepsis in the neonatal intensive care unit (NICU). This study was a prospective cohort study. During the 13-month study, 84 infants underwent 116 sepsis evaluations, and CMV DNA was detected in saliva in three (4%) infants (median: gestational age 28 weeks, birth weight 950 g), representing 5% (n=6) of all sepsis evaluations. One infant had CMV DNA detected in saliva in all four sepsis evaluations. Two infants had acquired CMV infection, while the timing of CMV acquisition could not be determined in one infant. Two of the three infants had concomitant Gram-negative bacteremia and urinary tract infections (UTIs), two developed severe bronchopulmonary dysplasia (BPD) and none died. Detection of CMV DNA in saliva occurred in 4% of infants and 5% of sepsis evaluations. Persistence of CMV DNA shedding in saliva made attribution of clinical illness difficult to ascertain.
KW - Acquired cytomegalovirus infection
KW - cytomegalovirus infection
KW - neonatal sepsis
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U2 - 10.1515/jpm-2018-0021
DO - 10.1515/jpm-2018-0021
M3 - Article
AN - SCOPUS:85047496822
VL - 47
SP - 90
EP - 98
JO - Journal of Perinatal Medicine
JF - Journal of Perinatal Medicine
SN - 0300-5577
IS - 1
ER -