Detection of drug-dependent IgG antibodies with antiplatelet activity by the antiglobulin consumption assay

L. Conti, P. Fidani, A. Chistolini, M. Francesconi, G. M. Gandolfo, M. G. Mazzucconi

Research output: Contribution to journalArticle

Abstract

Drug-induced thrombocytopenia is a common acquired hemorrhagic disorder. In this study 32 patients with drug-induced thrombocytopenia were examined with the antiglobulin consumption assay. Platelet-associated IgG was elevated in 19 of 20 patients that were analyzed. An increase in serum platelet bindable IgG was observed in 24 subjects after the addition of various drugs (acetylsalicylic acid, noraminopyrine, antibiotics, sulfamides, digoxin, heparin and chenodeoxycholic acid). These findings are significant for the presence of drug-dependent platelet antibodies.

Original languageEnglish
Pages (from-to)480-486
Number of pages7
JournalHaemostasis
Volume14
Issue number6
Publication statusPublished - 1984

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Anti-Idiotypic Antibodies
Immunoglobulin G
Blood Platelets
Antibodies
Thrombocytopenia
Pharmaceutical Preparations
Hemorrhagic Disorders
Chenodeoxycholic Acid
Digoxin
Aspirin
Heparin
Anti-Bacterial Agents
Serum

ASJC Scopus subject areas

  • Hematology

Cite this

Conti, L., Fidani, P., Chistolini, A., Francesconi, M., Gandolfo, G. M., & Mazzucconi, M. G. (1984). Detection of drug-dependent IgG antibodies with antiplatelet activity by the antiglobulin consumption assay. Haemostasis, 14(6), 480-486.

Detection of drug-dependent IgG antibodies with antiplatelet activity by the antiglobulin consumption assay. / Conti, L.; Fidani, P.; Chistolini, A.; Francesconi, M.; Gandolfo, G. M.; Mazzucconi, M. G.

In: Haemostasis, Vol. 14, No. 6, 1984, p. 480-486.

Research output: Contribution to journalArticle

Conti, L, Fidani, P, Chistolini, A, Francesconi, M, Gandolfo, GM & Mazzucconi, MG 1984, 'Detection of drug-dependent IgG antibodies with antiplatelet activity by the antiglobulin consumption assay', Haemostasis, vol. 14, no. 6, pp. 480-486.
Conti L, Fidani P, Chistolini A, Francesconi M, Gandolfo GM, Mazzucconi MG. Detection of drug-dependent IgG antibodies with antiplatelet activity by the antiglobulin consumption assay. Haemostasis. 1984;14(6):480-486.
Conti, L. ; Fidani, P. ; Chistolini, A. ; Francesconi, M. ; Gandolfo, G. M. ; Mazzucconi, M. G. / Detection of drug-dependent IgG antibodies with antiplatelet activity by the antiglobulin consumption assay. In: Haemostasis. 1984 ; Vol. 14, No. 6. pp. 480-486.
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