Detection of eight β-thalassemia mutations using a DNA enzyme immunoassay

A. Colosimo, G. Novelli, A. Cavicchini, B. Dallapiccola

Research output: Contribution to journalArticle

Abstract

We describe the use of a polymerase chain reaction-based method followed by a DNA enzyme immunoassay for the simultaneous detection of the eight most common β-thalassemia mutations in the Mediterranean population. The method is specific, sensitive, and easily applicable in routine clinical laboratories for the molecular diagnosis of β-thalassemia patients and at risk couples.

Original languageEnglish
Pages (from-to)136-139
Number of pages4
JournalInternational Journal of Clinical & Laboratory Research
Volume26
Issue number2
DOIs
Publication statusPublished - Jul 1996

Keywords

  • β-Thalassemia
  • DNA enzyme immunoassay
  • Polymerase chain reaction
  • Screening

ASJC Scopus subject areas

  • Clinical Biochemistry

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