Detection of GD2-positive cells in bone marrow samples and survival of patients with localised neuroblastoma

M. V. Corrias, S. Parodi, R. Haupt, L. Lacitignola, F. Negri, A. R. Sementa, D. Dau, F. Scuderi, B. Carlini, M. Bianchi, F. Casale, L. Faulkner, A. Garaventa

Research output: Contribution to journalArticlepeer-review

Abstract

The impact of bone marrow (BM) GD2-positive cells on survival has been evaluated in 145 Italian children with localised neuroblastoma (NB) evaluated at diagnosis by anti-GD2 immunocytochemistry. Nineteen of these (13.1%) were found to be BM GD2-positive, with the number of positive cells ranging between 1 and 155 out of 1 × 106 total cells analysed. Seven/19 (38.8%) GD2-positive vs 12/126 (9.5%) GD2-negative patients relapsed. The 5-year event-free survival (EFS) and overall survival of the GD2-positive patients was significantly worse than that of the GD2-negative ones (62.2 vs 89.9%, P

Original languageEnglish
Pages (from-to)263-269
Number of pages7
JournalBritish Journal of Cancer
Volume98
Issue number2
DOIs
Publication statusPublished - Jan 29 2008

Keywords

  • Detection
  • GD2
  • Immunocytochemistry
  • Neuroblastoma
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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