Detection of GD2-positive cells in bone marrow samples and survival of patients with localised neuroblastoma

M. V. Corrias; S. Parodi; R. Haupt; L. Lacitignola; F. Negri; A. R. Sementa; D. Dau; F. Scuderi; B. Carlini; M. Bianchi; F. Casale; L. Faulkner; A. Garaventa

doi:10.1038/sj.bjc.6604179

Detection of GD2-positive cells in bone marrow samples and survival of patients with localised neuroblastoma

M. V. Corrias, S. Parodi, R. Haupt, L. Lacitignola, F. Negri, A. R. Sementa, D. Dau, F. Scuderi, B. Carlini, M. Bianchi, F. Casale, L. Faulkner, A. Garaventa

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

The impact of bone marrow (BM) GD2-positive cells on survival has been evaluated in 145 Italian children with localised neuroblastoma (NB) evaluated at diagnosis by anti-GD2 immunocytochemistry. Nineteen of these (13.1%) were found to be BM GD2-positive, with the number of positive cells ranging between 1 and 155 out of 1 × 10⁶ total cells analysed. Seven/19 (38.8%) GD2-positive vs 12/126 (9.5%) GD2-negative patients relapsed. The 5-year event-free survival (EFS) and overall survival of the GD2-positive patients was significantly worse than that of the GD2-negative ones (62.2 vs 89.9%, P

Original language	English
Pages (from-to)	263-269
Number of pages	7
Journal	British Journal of Cancer
Volume	98
Issue number	2
DOIs	https://doi.org/10.1038/sj.bjc.6604179
Publication status	Published - Jan 29 2008

Keywords

Detection
GD2
Immunocytochemistry
Neuroblastoma
Survival

ASJC Scopus subject areas

Cancer Research
Oncology

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Corrias, M. V., Parodi, S., Haupt, R., Lacitignola, L., Negri, F., Sementa, A. R., Dau, D., Scuderi, F., Carlini, B., Bianchi, M., Casale, F., Faulkner, L., & Garaventa, A. (2008). Detection of GD2-positive cells in bone marrow samples and survival of patients with localised neuroblastoma. British Journal of Cancer, 98(2), 263-269. https://doi.org/10.1038/sj.bjc.6604179

Detection of GD2-positive cells in bone marrow samples and survival of patients with localised neuroblastoma. / Corrias, M. V.; Parodi, S.; Haupt, R.; Lacitignola, L.; Negri, F.; Sementa, A. R.; Dau, D.; Scuderi, F.; Carlini, B.; Bianchi, M.; Casale, F.; Faulkner, L.; Garaventa, A.

In: British Journal of Cancer, Vol. 98, No. 2, 29.01.2008, p. 263-269.

Research output: Contribution to journal › Article › peer-review

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abstract = "The impact of bone marrow (BM) GD2-positive cells on survival has been evaluated in 145 Italian children with localised neuroblastoma (NB) evaluated at diagnosis by anti-GD2 immunocytochemistry. Nineteen of these (13.1%) were found to be BM GD2-positive, with the number of positive cells ranging between 1 and 155 out of 1 × 106 total cells analysed. Seven/19 (38.8%) GD2-positive vs 12/126 (9.5%) GD2-negative patients relapsed. The 5-year event-free survival (EFS) and overall survival of the GD2-positive patients was significantly worse than that of the GD2-negative ones (62.2 vs 89.9%, P",

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AU - Sementa, A. R.

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AU - Scuderi, F.

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