Abstract
The impact of bone marrow (BM) GD2-positive cells on survival has been evaluated in 145 Italian children with localised neuroblastoma (NB) evaluated at diagnosis by anti-GD2 immunocytochemistry. Nineteen of these (13.1%) were found to be BM GD2-positive, with the number of positive cells ranging between 1 and 155 out of 1 × 106 total cells analysed. Seven/19 (38.8%) GD2-positive vs 12/126 (9.5%) GD2-negative patients relapsed. The 5-year event-free survival (EFS) and overall survival of the GD2-positive patients was significantly worse than that of the GD2-negative ones (62.2 vs 89.9%, P
Original language | English |
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Pages (from-to) | 263-269 |
Number of pages | 7 |
Journal | British Journal of Cancer |
Volume | 98 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jan 29 2008 |
Keywords
- Detection
- GD2
- Immunocytochemistry
- Neuroblastoma
- Survival
ASJC Scopus subject areas
- Cancer Research
- Oncology