Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry

G. B. Frisoni, C. Testa, A. Zorzan, F. Sabattoli, A. Beltramello, H. Soininen, M. P. Laakso

Research output: Contribution to journalArticlepeer-review


Objectives: To test the applicability of an automated method of magnetic resonance image analysis (voxel based morphometry) to detect presence and severity of regional grey matter density reduction - a proxy of atrophy - in Alzheimer's disease. Methods: Twenty nine probable Alzheimer's patients and 26 non-demented controls (mini-mental state examinations mean (SD) 21 (4) and 29 (1)) underwent high resolution 3D brain magnetic resonance imaging. Spatial normalisation to a stereotactic template, segmentation into grey matter, white matter, and cerebrospinal fluid, and smoothing of the grey matter were carried out based on statistical parametric mapping (SPM99) algorithms. Analyses were carried out: (a) contrasting all Alzheimer's patients with all controls (p

Original languageEnglish
Pages (from-to)657-664
Number of pages8
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number6
Publication statusPublished - Dec 1 2002

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health


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