TY - JOUR
T1 - Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry
AU - Frisoni, G. B.
AU - Testa, C.
AU - Zorzan, A.
AU - Sabattoli, F.
AU - Beltramello, A.
AU - Soininen, H.
AU - Laakso, M. P.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Objectives: To test the applicability of an automated method of magnetic resonance image analysis (voxel based morphometry) to detect presence and severity of regional grey matter density reduction - a proxy of atrophy - in Alzheimer's disease. Methods: Twenty nine probable Alzheimer's patients and 26 non-demented controls (mini-mental state examinations mean (SD) 21 (4) and 29 (1)) underwent high resolution 3D brain magnetic resonance imaging. Spatial normalisation to a stereotactic template, segmentation into grey matter, white matter, and cerebrospinal fluid, and smoothing of the grey matter were carried out based on statistical parametric mapping (SPM99) algorithms. Analyses were carried out: (a) contrasting all Alzheimer's patients with all controls (p
AB - Objectives: To test the applicability of an automated method of magnetic resonance image analysis (voxel based morphometry) to detect presence and severity of regional grey matter density reduction - a proxy of atrophy - in Alzheimer's disease. Methods: Twenty nine probable Alzheimer's patients and 26 non-demented controls (mini-mental state examinations mean (SD) 21 (4) and 29 (1)) underwent high resolution 3D brain magnetic resonance imaging. Spatial normalisation to a stereotactic template, segmentation into grey matter, white matter, and cerebrospinal fluid, and smoothing of the grey matter were carried out based on statistical parametric mapping (SPM99) algorithms. Analyses were carried out: (a) contrasting all Alzheimer's patients with all controls (p
UR - http://www.scopus.com/inward/record.url?scp=0036904784&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036904784&partnerID=8YFLogxK
U2 - 10.1136/jnnp.73.6.657
DO - 10.1136/jnnp.73.6.657
M3 - Article
C2 - 12438466
AN - SCOPUS:0036904784
VL - 73
SP - 657
EP - 664
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 6
ER -