Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry

G. B. Frisoni; C. Testa; A. Zorzan; F. Sabattoli; A. Beltramello; H. Soininen; M. P. Laakso

doi:10.1136/jnnp.73.6.657

Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry

G. B. Frisoni, C. Testa, A. Zorzan, F. Sabattoli, A. Beltramello, H. Soininen, M. P. Laakso

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To test the applicability of an automated method of magnetic resonance image analysis (voxel based morphometry) to detect presence and severity of regional grey matter density reduction - a proxy of atrophy - in Alzheimer's disease. Methods: Twenty nine probable Alzheimer's patients and 26 non-demented controls (mini-mental state examinations mean (SD) 21 (4) and 29 (1)) underwent high resolution 3D brain magnetic resonance imaging. Spatial normalisation to a stereotactic template, segmentation into grey matter, white matter, and cerebrospinal fluid, and smoothing of the grey matter were carried out based on statistical parametric mapping (SPM99) algorithms. Analyses were carried out: (a) contrasting all Alzheimer's patients with all controls (p

Original language	English
Pages (from-to)	657-664
Number of pages	8
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	73
Issue number	6
DOIs	https://doi.org/10.1136/jnnp.73.6.657
Publication status	Published - Dec 1 2002

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Neuroscience(all)
Psychiatry and Mental health

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AU - Zorzan, A.

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AU - Beltramello, A.

AU - Soininen, H.

AU - Laakso, M. P.

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