Detection of high levels of Survivin-immunoglobulin M immune complex in sera from hepatitis C virus infected patients with cirrhosis

Claudia Matteucci, Roberta Sorrentino, Lia Bellis, Giuseppe Maria Ettorre, Valentina Svicher, Roberto Santoro, Giovanni Vennarecci, Alessandra Biasiolo, Patrizia Pontisso, Daria Scacciatelli, Luca Beneduce, Cesare Sarrecchia, Paolo Casalino, Sergio Bernardini, Pasquale Pierimarchi, Enrico Garaci, Claudio Puoti, Guido Rasi

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: The identification and surveillance of patients with liver dysfunctions and the discovering of new disease biomarkers are needed in the clinical practice. The aim of this study was to investigate on Survivin-immunoglobulin (Ig)M immune complex (IC) as a potential biomarker of chronic liver diseases. Methods: Serum levels of Survivin-IgM were measured using an enzyme-linked immunoassay that had been standardized and validated in our laboratory in 262 individuals, including healthy subjects and patients with chronic viral hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Results: Survivin-IgM IC was lower in healthy subjects (median, 99.39 AU/mL) than in patients with chronic viral hepatitis (median, 148.03 AU/mL; P=0.002) or with cirrhosis (median, 371.00 AU/mL; P

Original languageEnglish
Pages (from-to)1008-1018
Number of pages11
JournalHepatology Research
Volume44
Issue number9
DOIs
Publication statusPublished - Sep 1 2014

Keywords

  • Disease biomarkers
  • Hepatitis C
  • Hepatocellular carcinoma
  • Immune complexes
  • Liver cirrhosis
  • Survivin

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

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