Detection of human herpesviruses and polyomaviruses DNA in a group of patients with relapsing-remitting multiple sclerosis

Valeria Pietropaolo, Daniela Fioriti, Monica Mischitelli, Elena Anzivino, Manuela Santini, Enrico Millefiorini, Simone Di Rezze, Anna Marta Degener

Research output: Contribution to journalArticle

Abstract

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system whose pathological features consist of white matter plaques of primary demyelinization and loss of oligodendrocytes. Various risk factors have been associated with MS susceptibility. We have focused this study on different viruses. In particular in the present study we used PCR to search for the genomic DNA of HHV-1, HHV-2, HHV-8, BKV and JCV in urine and peripheral blood mononuclear cells (PBMC) samples from 44 relapsing-remitting MS (RRMS) patients. No viral DNA was found in any urine sample, whereas 29.5% of RRMS PBMC samples were positive. It is suggestive that Human herpesviruses (HHV-1 and HHV-8) were constantly present in all positive samples, indicating that viral agents could contribute to create the demyelination plaques and cause MS.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalNew Microbiologica
Volume28
Issue number3
Publication statusPublished - Jul 2005

Fingerprint

Relapsing-Remitting Multiple Sclerosis
Polyomavirus
Herpesviridae
Human Herpesvirus 1
Multiple Sclerosis
Human Herpesvirus 8
DNA
Blood Cells
Urine
Human Herpesvirus 2
Central Nervous System Diseases
Oligodendroglia
Viral DNA
Demyelinating Diseases
Viruses
Polymerase Chain Reaction

Keywords

  • BKV
  • HHV-1
  • HHV-2
  • HHV-8
  • JCV
  • MS

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Pietropaolo, V., Fioriti, D., Mischitelli, M., Anzivino, E., Santini, M., Millefiorini, E., ... Degener, A. M. (2005). Detection of human herpesviruses and polyomaviruses DNA in a group of patients with relapsing-remitting multiple sclerosis. New Microbiologica, 28(3), 199-203.

Detection of human herpesviruses and polyomaviruses DNA in a group of patients with relapsing-remitting multiple sclerosis. / Pietropaolo, Valeria; Fioriti, Daniela; Mischitelli, Monica; Anzivino, Elena; Santini, Manuela; Millefiorini, Enrico; Di Rezze, Simone; Degener, Anna Marta.

In: New Microbiologica, Vol. 28, No. 3, 07.2005, p. 199-203.

Research output: Contribution to journalArticle

Pietropaolo, V, Fioriti, D, Mischitelli, M, Anzivino, E, Santini, M, Millefiorini, E, Di Rezze, S & Degener, AM 2005, 'Detection of human herpesviruses and polyomaviruses DNA in a group of patients with relapsing-remitting multiple sclerosis', New Microbiologica, vol. 28, no. 3, pp. 199-203.
Pietropaolo V, Fioriti D, Mischitelli M, Anzivino E, Santini M, Millefiorini E et al. Detection of human herpesviruses and polyomaviruses DNA in a group of patients with relapsing-remitting multiple sclerosis. New Microbiologica. 2005 Jul;28(3):199-203.
Pietropaolo, Valeria ; Fioriti, Daniela ; Mischitelli, Monica ; Anzivino, Elena ; Santini, Manuela ; Millefiorini, Enrico ; Di Rezze, Simone ; Degener, Anna Marta. / Detection of human herpesviruses and polyomaviruses DNA in a group of patients with relapsing-remitting multiple sclerosis. In: New Microbiologica. 2005 ; Vol. 28, No. 3. pp. 199-203.
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