Recent strong evidence linking human papilloma virus (HPV) with cervival carcinoma comes from the occurrence of particles, antigens, and DNA fragments of this virus in preneoplastic lesions and in a limited number of malignant tumors. The aim of the present work was to detect, by molecular hybridization, HPV viral sequences, in order to improve early diagnosis, based on the occurrence of molecular markers in apparently normal cells collected by cervical scrapes. We have screened by HPV DNA hybridization 239 cervical scrapes of a random population of women and 20 tumors of the female genital tract. 19.8% positivity was founded in those specimens in which morphological examination indicated the occurrence of mainly normal exfoliative cells. These data, correlated with over 90% positivity found in tested tumors, suggest that hybridization with HPV probes may improve the early diagnosis in female genital tract tumors and open the way for a mass screening program.
|Number of pages||2|
|Journal||Medical Science Research|
|Publication status||Published - 1987|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)