Detection of immunoglobulins G and A on the cell membrane of hepatocytes from patients with alcoholic liver disease

A. Trevisan; R. Cavigli; R. Meliconi; G. F. Stefanini; S. Zotti; M. Rugge; F. Noventa; C. Betterle; G. Realdi

Detection of immunoglobulins G and A on the cell membrane of hepatocytes from patients with alcoholic liver disease

A. Trevisan, R. Cavigli, R. Meliconi, G. F. Stefanini, S. Zotti, M. Rugge, F. Noventa, C. Betterle, G. Realdi

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

The presence of immunoglobulins (Ig) G, A, and M and of complement fractions (C3-C4) on the liver cell surface was investigated by direct immunofluorescence in 40 patients with alcoholic liver disease. IgG was detected on the liver cell membrane with a linear staining pattern in 29 patients. The percentage of IgG-positive hepatocytes correlated with transaminase activities, independently of the histological findings. IgA was demonstrable with a coarse granular staining pattern in 11 of the 14 cases with established cirrhosis. The finding of IgG bound to the hepatocyte surface in patients with alcohol-induced liver damage suggests that alcohol could be responsible for antigenic modifications of hepatocyte membrane with consequent triggering of a humoral immune response.

Original language	English
Pages (from-to)	530-534
Number of pages	5
Journal	Journal of Clinical Pathology
Volume	36
Issue number	5
Publication status	Published - 1983

ASJC Scopus subject areas

Pathology and Forensic Medicine

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Detection of immunoglobulins G and A on the cell membrane of hepatocytes from patients with alcoholic liver disease. / Trevisan, A.; Cavigli, R.; Meliconi, R.; Stefanini, G. F.; Zotti, S.; Rugge, M.; Noventa, F.; Betterle, C.; Realdi, G.

In: Journal of Clinical Pathology, Vol. 36, No. 5, 1983, p. 530-534.

Research output: Contribution to journal › Article › peer-review

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abstract = "The presence of immunoglobulins (Ig) G, A, and M and of complement fractions (C3-C4) on the liver cell surface was investigated by direct immunofluorescence in 40 patients with alcoholic liver disease. IgG was detected on the liver cell membrane with a linear staining pattern in 29 patients. The percentage of IgG-positive hepatocytes correlated with transaminase activities, independently of the histological findings. IgA was demonstrable with a coarse granular staining pattern in 11 of the 14 cases with established cirrhosis. The finding of IgG bound to the hepatocyte surface in patients with alcohol-induced liver damage suggests that alcohol could be responsible for antigenic modifications of hepatocyte membrane with consequent triggering of a humoral immune response.",

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AU - Zotti, S.

AU - Rugge, M.

AU - Noventa, F.

AU - Betterle, C.

AU - Realdi, G.

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AB - The presence of immunoglobulins (Ig) G, A, and M and of complement fractions (C3-C4) on the liver cell surface was investigated by direct immunofluorescence in 40 patients with alcoholic liver disease. IgG was detected on the liver cell membrane with a linear staining pattern in 29 patients. The percentage of IgG-positive hepatocytes correlated with transaminase activities, independently of the histological findings. IgA was demonstrable with a coarse granular staining pattern in 11 of the 14 cases with established cirrhosis. The finding of IgG bound to the hepatocyte surface in patients with alcohol-induced liver damage suggests that alcohol could be responsible for antigenic modifications of hepatocyte membrane with consequent triggering of a humoral immune response.

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