Detection of immunoglobulins G and A on the cell membrane of hepatocytes from patients with alcoholic liver disease

A. Trevisan, R. Cavigli, R. Meliconi, G. F. Stefanini, S. Zotti, M. Rugge, F. Noventa, C. Betterle, G. Realdi

Research output: Contribution to journalArticlepeer-review

Abstract

The presence of immunoglobulins (Ig) G, A, and M and of complement fractions (C3-C4) on the liver cell surface was investigated by direct immunofluorescence in 40 patients with alcoholic liver disease. IgG was detected on the liver cell membrane with a linear staining pattern in 29 patients. The percentage of IgG-positive hepatocytes correlated with transaminase activities, independently of the histological findings. IgA was demonstrable with a coarse granular staining pattern in 11 of the 14 cases with established cirrhosis. The finding of IgG bound to the hepatocyte surface in patients with alcohol-induced liver damage suggests that alcohol could be responsible for antigenic modifications of hepatocyte membrane with consequent triggering of a humoral immune response.

Original languageEnglish
Pages (from-to)530-534
Number of pages5
JournalJournal of Clinical Pathology
Volume36
Issue number5
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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