Abstract
The presence of immunoglobulins (Ig) G, A, and M and of complement fractions (C3-C4) on the liver cell surface was investigated by direct immunofluorescence in 40 patients with alcoholic liver disease. IgG was detected on the liver cell membrane with a linear staining pattern in 29 patients. The percentage of IgG-positive hepatocytes correlated with transaminase activities, independently of the histological findings. IgA was demonstrable with a coarse granular staining pattern in 11 of the 14 cases with established cirrhosis. The finding of IgG bound to the hepatocyte surface in patients with alcohol-induced liver damage suggests that alcohol could be responsible for antigenic modifications of hepatocyte membrane with consequent triggering of a humoral immune response.
| Original language | English |
|---|---|
| Pages (from-to) | 530-534 |
| Number of pages | 5 |
| Journal | Journal of Clinical Pathology |
| Volume | 36 |
| Issue number | 5 |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
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Detection of immunoglobulins G and A on the cell membrane of hepatocytes from patients with alcoholic liver disease. / Trevisan, A.; Cavigli, R.; Meliconi, R.; Stefanini, G. F.; Zotti, S.; Rugge, M.; Noventa, F.; Betterle, C.; Realdi, G.
In: Journal of Clinical Pathology, Vol. 36, No. 5, 1983, p. 530-534.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Detection of immunoglobulins G and A on the cell membrane of hepatocytes from patients with alcoholic liver disease
AU - Trevisan, A.
AU - Cavigli, R.
AU - Meliconi, R.
AU - Stefanini, G. F.
AU - Zotti, S.
AU - Rugge, M.
AU - Noventa, F.
AU - Betterle, C.
AU - Realdi, G.
PY - 1983
Y1 - 1983
N2 - The presence of immunoglobulins (Ig) G, A, and M and of complement fractions (C3-C4) on the liver cell surface was investigated by direct immunofluorescence in 40 patients with alcoholic liver disease. IgG was detected on the liver cell membrane with a linear staining pattern in 29 patients. The percentage of IgG-positive hepatocytes correlated with transaminase activities, independently of the histological findings. IgA was demonstrable with a coarse granular staining pattern in 11 of the 14 cases with established cirrhosis. The finding of IgG bound to the hepatocyte surface in patients with alcohol-induced liver damage suggests that alcohol could be responsible for antigenic modifications of hepatocyte membrane with consequent triggering of a humoral immune response.
AB - The presence of immunoglobulins (Ig) G, A, and M and of complement fractions (C3-C4) on the liver cell surface was investigated by direct immunofluorescence in 40 patients with alcoholic liver disease. IgG was detected on the liver cell membrane with a linear staining pattern in 29 patients. The percentage of IgG-positive hepatocytes correlated with transaminase activities, independently of the histological findings. IgA was demonstrable with a coarse granular staining pattern in 11 of the 14 cases with established cirrhosis. The finding of IgG bound to the hepatocyte surface in patients with alcohol-induced liver damage suggests that alcohol could be responsible for antigenic modifications of hepatocyte membrane with consequent triggering of a humoral immune response.
UR - http://www.scopus.com/inward/record.url?scp=0020560938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020560938&partnerID=8YFLogxK
M3 - Article
VL - 36
SP - 530
EP - 534
JO - Journal of Clinical Pathology - Clinical Molecular Pathology
JF - Journal of Clinical Pathology - Clinical Molecular Pathology
SN - 0021-9746
IS - 5
ER -