Detection of interleukin-2 in addition to interferon-γ discriminates active tuberculosis patients, latently infected individuals, and controls

R. Biselli; S. Mariotti; V. Sargentini; I. Sauzullo; M. Lastilla; F. Mengoni; V. Vanini; E. Girardi; D. Goletti; R. D'Amelio; R. Nisini

doi:10.1111/j.1469-0691.2009.03104.x

Detection of interleukin-2 in addition to interferon-γ discriminates active tuberculosis patients, latently infected individuals, and controls

R. Biselli, S. Mariotti, V. Sargentini, I. Sauzullo, M. Lastilla, F. Mengoni, V. Vanini, E. Girardi, D. Goletti, R. D'Amelio, R. Nisini

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Effective control of tuberculosis (TB) includes discrimination of subjects with active TB from individuals with latent TB infection (LTBI). As distinct interferon (IFN)-γ and interleukin (IL)-2 profiles of antigen-specific T-cells have been associated with different clinical stages and antigen loads in several viral and bacterial diseases, we analysed these cytokines in TB using a modified QuantiFERON-TB Gold In Tube test. Detection of IL-2 in addition to IFN-γ distinguishes not only Mycobacterium tuberculosis-infected subjects from healthy controls, but also individuals with LTBI from active TB patients. This may help to improve diagnostic tests for TB.

Original language	English
Pages (from-to)	1282-1284
Number of pages	3
Journal	Clinical Microbiology and Infection
Volume	16
Issue number	8
DOIs	https://doi.org/10.1111/j.1469-0691.2009.03104.x
Publication status	Published - 2010

Keywords

Diagnosis
IFN-γ
IL-2
Latent infection
Tuberculosis

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Medicine(all)

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Biselli, R., Mariotti, S., Sargentini, V., Sauzullo, I., Lastilla, M., Mengoni, F., Vanini, V., Girardi, E., Goletti, D., D'Amelio, R., & Nisini, R. (2010). Detection of interleukin-2 in addition to interferon-γ discriminates active tuberculosis patients, latently infected individuals, and controls. Clinical Microbiology and Infection, 16(8), 1282-1284. https://doi.org/10.1111/j.1469-0691.2009.03104.x

Detection of interleukin-2 in addition to interferon-γ discriminates active tuberculosis patients, latently infected individuals, and controls. / Biselli, R.; Mariotti, S.; Sargentini, V.; Sauzullo, I.; Lastilla, M.; Mengoni, F.; Vanini, V.; Girardi, E.; Goletti, D.; D'Amelio, R.; Nisini, R.

In: Clinical Microbiology and Infection, Vol. 16, No. 8, 2010, p. 1282-1284.

Research output: Contribution to journal › Article › peer-review

Biselli, R, Mariotti, S, Sargentini, V, Sauzullo, I, Lastilla, M, Mengoni, F, Vanini, V, Girardi, E , Goletti, D, D'Amelio, R & Nisini, R 2010, 'Detection of interleukin-2 in addition to interferon-γ discriminates active tuberculosis patients, latently infected individuals, and controls', Clinical Microbiology and Infection, vol. 16, no. 8, pp. 1282-1284. https://doi.org/10.1111/j.1469-0691.2009.03104.x

Biselli, R. ; Mariotti, S. ; Sargentini, V. ; Sauzullo, I. ; Lastilla, M. ; Mengoni, F. ; Vanini, V. ; Girardi, E. ; Goletti, D. ; D'Amelio, R. ; Nisini, R. / Detection of interleukin-2 in addition to interferon-γ discriminates active tuberculosis patients, latently infected individuals, and controls. In: Clinical Microbiology and Infection. 2010 ; Vol. 16, No. 8. pp. 1282-1284.

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