Detection of interleukin-2 in addition to interferon-γ discriminates active tuberculosis patients, latently infected individuals, and controls

R. Biselli, S. Mariotti, V. Sargentini, I. Sauzullo, M. Lastilla, F. Mengoni, V. Vanini, E. Girardi, D. Goletti, R. D'Amelio, R. Nisini

Research output: Contribution to journalArticlepeer-review

Abstract

Effective control of tuberculosis (TB) includes discrimination of subjects with active TB from individuals with latent TB infection (LTBI). As distinct interferon (IFN)-γ and interleukin (IL)-2 profiles of antigen-specific T-cells have been associated with different clinical stages and antigen loads in several viral and bacterial diseases, we analysed these cytokines in TB using a modified QuantiFERON-TB Gold In Tube test. Detection of IL-2 in addition to IFN-γ distinguishes not only Mycobacterium tuberculosis-infected subjects from healthy controls, but also individuals with LTBI from active TB patients. This may help to improve diagnostic tests for TB.

Original languageEnglish
Pages (from-to)1282-1284
Number of pages3
JournalClinical Microbiology and Infection
Volume16
Issue number8
DOIs
Publication statusPublished - 2010

Keywords

  • Diagnosis
  • IFN-γ
  • IL-2
  • Latent infection
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

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