Abstract
Effective control of tuberculosis (TB) includes discrimination of subjects with active TB from individuals with latent TB infection (LTBI). As distinct interferon (IFN)-γ and interleukin (IL)-2 profiles of antigen-specific T-cells have been associated with different clinical stages and antigen loads in several viral and bacterial diseases, we analysed these cytokines in TB using a modified QuantiFERON-TB Gold In Tube test. Detection of IL-2 in addition to IFN-γ distinguishes not only Mycobacterium tuberculosis-infected subjects from healthy controls, but also individuals with LTBI from active TB patients. This may help to improve diagnostic tests for TB.
Original language | English |
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Pages (from-to) | 1282-1284 |
Number of pages | 3 |
Journal | Clinical Microbiology and Infection |
Volume | 16 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- Diagnosis
- IFN-γ
- IL-2
- Latent infection
- Tuberculosis
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
- Medicine(all)