Detection of leptomeningeal involvement by 18F-FDG-PET/CT in a patient with non-Hodgkin lymphoma

Rosa Fonti, Barbara Salvatore, Amalia De Renzo, Emanuele Nicolai, Silvana Del Vecchio

Research output: Contribution to journalArticlepeer-review


Leptomeningeal infiltration of the brain or spinal cord by neoplastic cells may occur as complication of solid or hematopoietic tumors such as non-Hodgkin lymphoma. Previously rare, this event is becoming increasingly common as newer therapies can prolong survival but may not achieve therapeutic concentration in the central nervous system. Although prognosis is poor, early diagnosis and aggressive treatment may lead to prolonged survival and/or improvement of quality of life. We report a case of a 69-year-old man with leptomeningeal infiltration by non-Hodgkin lymphoma revealed by 18F-FDG-PET/CT and confirmed by subsequent spinal MRI and cerebrospinal fluid cytology.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalClinical Nuclear Medicine
Issue number2
Publication statusPublished - Nov 6 2015


  • Leptomeningeal involvement
  • MRI
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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