Purpose: So far, no studies comparing 18F-Fluoride-PET/CT and MDCT for the detection of bone metastases are available. We compared the accuracy of 18F-Fluoride-PET/CT (MDCT: 3.75 mm thickness-image- reconstruction), whole-body Multi-Detector-CT (MDCT: 1.25 mm thickness-image-reconstruction) and 18F-Fluoride-PET/MDCT (MDCT: 1.25 mm thickness-image-reconstruction) in identifying bone metastases in breast cancer patients. Methods: We studied 39 breast cancer patients for bone metastases. Imaging was performed on an integrated PET/MDCT-system; CT images were reconstructed at 3.75 mm and 1.25 mm thickness. Two nuclear medicine physicians and one radiologist interpreted blindly 18F-Fluoride-PET/ CT, 18F-Fluoride-PET/MDCT and MDCT. MDCT at 12 months served as the standard of reference. Results: Overall, 662 bone lesions were detected in our analysis. Of these, 542 were malignant and 120 were benign according to the standard of reference. 18F-Fluoride-PET/CT detected 491 bone metastases, 114 (23%) of which displayed no clear morphological changes on MDCT, whereas MDCT detected 416 bone metastases, 39 (9.3%) of which showed no 18F-Fluoride-PET uptake. Overall sensitivity and specificity were: 91% and 91%, respectively, for 18F-Fluoride-PET/CT, and 77% and 93% for MDCT. The integrated assessment of 18F-Fluoride-PET/MDCT yielded sensitivity and specificity values of 98% and 93%, respectively. Conclusions: 18F-Fluoride-PET/MDCT has higher diagnostic accuracy than 18F-Fluoride-PET/CT and MDCT for the evaluation of bone metastases in breast cancer.
- Bone metastases
- Breast cancer
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging