Abstract
Allogeneic stem cell transplantation (allo-SCT) is an effective and potentially curative treatment for some cases of multiple myeloma (MM). The curative efficacy of allo-SCT may be largely attributed to its immunological activity, the graft-versus-myeloma (GVM) effect. To evaluate the kinetics of residual myeloma cells, we analyzed the follow-up bone marrow samples of three MM patients by means of a real-time molecular assay. We identified a consistent correlation between onset of graft-versus-host disease and disease response. These data suggest that real-time molecular follow-up can be used to monitor the GVM effect and that it can be employed in the clinical setting to tailor post transplant immunomodulation.
Original language | English |
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Pages (from-to) | 791-793 |
Number of pages | 3 |
Journal | Bone Marrow Transplantation |
Volume | 32 |
Issue number | 8 |
DOIs | |
Publication status | Published - Oct 2003 |
Keywords
- Allogeneic transplantation
- Graft-versus-myeloma
- Multiple myeloma
- Real-time PCR
ASJC Scopus subject areas
- Hematology
- Transplantation