Detection of multiple sclerosis lesions using EPI-FLAIR images

Marco Rovaris, Giuseppe Iannucci, Clodoaldo Pereira, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journalArticlepeer-review


Fast fluid-attenuated inversion recovery (fast-FLAIR) sequences are very sensitive for detecting lesions of patients with multiple sclerosis (MS). Echo planar imaging allows to obtain FLAIR images (EPI-FLAIR) with significantly shorter scanning times. EPI-FLAIR images obtained with 10 measurements are as sensitive as fast-FLAIR for the detection of large MS lesions. Aim of this study was to compare the numbers of MS lesions seen on EPI-FLAIR images with fewer measurements (and, as a consequence, very short scanning times) with those seen on EPI-FLAIR images with 10 measurements. EPI-FLAIR scans with 2 (EPI-2), 4 (EPI-4), 6 (EPI-6), 8 (EPI-8) and 10 (EPI-10) measurements were obtained from 29 MS patients. Lesions seen using each of the five approaches were counted by agreement by two observers. EPI-10 images were used as the 'gold standard' for pairwise comparisons. EPI-FLAIR scans with fewer measurements (EPI-2, -4, -6, -8) were all significantly less sensitive than EPI-10 for the detection of small, intermediate and large MS lesions. All the EPI-FLAIR scans, however, fulfilled MR diagnostic criteria for definite MS. When rapid MR scanning of uncooperative MS patients is needed, EPI-FLAIR images coveting the entire brain in less than one minute may be considered. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)907-910
Number of pages4
JournalMagnetic Resonance Imaging
Issue number7
Publication statusPublished - 2000


  • Magnetic resonance
  • Multiple sclerosis

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics


Dive into the research topics of 'Detection of multiple sclerosis lesions using EPI-FLAIR images'. Together they form a unique fingerprint.

Cite this