TY - JOUR
T1 - Detection of phosphorylated insulin receptor in colorectal adenoma and adenocarcinoma
T2 - Implications for prognosis and clinical outcome
AU - Abbruzzese, Claudia
AU - Diodoro, Maria Grazia
AU - Sperduti, Isabella
AU - Mileo, Anna Maria
AU - Pattaro, Giada
AU - De Salvo, Laura
AU - Cosimelli, Maurizio
AU - Perrotti, Nicola
AU - Paggi, Marco G.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Colorectal carcinoma remains among the most frequent causes of cancer death. Besides the well-known genetic predisposition, a key role in colorectal adenoma and adenocarcinoma etio-pathogenesis, mainly in sporadic cases, is played by definite risk factors, such as obesity, type 2 diabetes, insulin resistance, hyper-insulinemia, and insulin therapy. These epidemiological data motivated us to determine, by means of immunohistochemistry, the amount of activated (phosphorylated) insulin receptor in archival samples from 22 colorectal adenoma and 117 adenocarcinoma patients, with the objective to estimate the role of this factor in colorectal epithelium transformation and cancer progression. Statistical analysis of the results clearly showed that positive staining for phosphorylated insulin receptor was significantly more frequent in adenomas than adenocarcinomas (P
AB - Colorectal carcinoma remains among the most frequent causes of cancer death. Besides the well-known genetic predisposition, a key role in colorectal adenoma and adenocarcinoma etio-pathogenesis, mainly in sporadic cases, is played by definite risk factors, such as obesity, type 2 diabetes, insulin resistance, hyper-insulinemia, and insulin therapy. These epidemiological data motivated us to determine, by means of immunohistochemistry, the amount of activated (phosphorylated) insulin receptor in archival samples from 22 colorectal adenoma and 117 adenocarcinoma patients, with the objective to estimate the role of this factor in colorectal epithelium transformation and cancer progression. Statistical analysis of the results clearly showed that positive staining for phosphorylated insulin receptor was significantly more frequent in adenomas than adenocarcinomas (P
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U2 - 10.1002/jcp.24733
DO - 10.1002/jcp.24733
M3 - Article
C2 - 25102778
AN - SCOPUS:84920896851
VL - 230
SP - 562
EP - 567
JO - Journal of cellular and comparative physiology
JF - Journal of cellular and comparative physiology
SN - 0021-9541
IS - 3
ER -