Detection of Polyomavirus in Merkel cell carcinoma by immunohistochemistry

report of three cases

F. Vaira, G. Nazzaro, F. Pesapane, L. Brambilla, A. Coggi, D. Fanoni, L. Venegoni, A. Tourlaki, R. Gianotti, E. Berti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin, arising from pluripotent precursors of Merkel cells. The tumor most frequently affects head and neck of elderly patients. It increases with sun exposure and after immunosuppression and organ transplantation. Because of a possible viral association, interest in MCC has escalated. A new polyomavirus, Merkel cell polyomavirus (MCPyV), was identified and associated to MCC. In support of this hypothesis, we report three new clinical cases of MCC in which we detected MCPyV by immunohistochemistry and provide an update on current thinking about the MCC.

Original languageEnglish
Pages (from-to)617-621
Number of pages5
JournalMinerva dermatologica
Volume150
Issue number5
Publication statusPublished - Oct 1 2015

Fingerprint

Merkel Cell Carcinoma
Polyomavirus
Immunohistochemistry
Merkel cell polyomavirus
Merkel Cells
Neuroendocrine Carcinoma
Organ Transplantation
Solar System
Immunosuppression
Neck
Head
Skin
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)
  • Dermatology

Cite this

Detection of Polyomavirus in Merkel cell carcinoma by immunohistochemistry : report of three cases. / Vaira, F.; Nazzaro, G.; Pesapane, F.; Brambilla, L.; Coggi, A.; Fanoni, D.; Venegoni, L.; Tourlaki, A.; Gianotti, R.; Berti, E.

In: Minerva dermatologica, Vol. 150, No. 5, 01.10.2015, p. 617-621.

Research output: Contribution to journalArticle

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