Detection of small bowel tumors by videocapsule endoscopy in patients with acromegaly.

C. L. Ronchi, F. Coletti, E. Fesce, L. Montefusco, C. Ogliari, E. Verrua, P. Epaminonda, E. Ferrante, E. Malchiodi, V. Morelli, P. Beck-Peccoz, M. Arosio

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Abstract

The prevalence of colon polyposis andmalignancies is increased in acromegalic patients as compared to the general population. An epidemiological study suggests a high prevalence also of small bowel (SB) tumors that nowadays may be detected by videocapsule endoscopy (VCE). The aim of the study was to assess the prevalence of SB neoplasms using VCE in acromegalic patients in comparison to control subjects and to correlate it with cancer risk factors and acromegaly-related parameters. Eighteen acromegalic patients (6 males and 12 females, age+/-SD: 54+/-10 yr), 5 cured after surgery (followed by radiotherapy in 3 cases) and 13 on pharmacological treatment were enrolled, and 36 sex- and age-matched non-acromegalic subjects served as a control group. Cancer risk factors, duration of acromegaly, GH and IGF-I levels, IGF binding protein 3 and IGF-II concentrations, metabolic parameters, tumor markers, colonic lesions by total colonoscopy, and SB lesions by VCE were investigated. VCE images suggestive of SB lesions were detected in 5/36 controls [14%, 4 described as gastrointestinal stromal nodular tumors (GIST), and 1 as polyp] and in 5/18 acromegalic patients [28%, 2 GIST and 3 polyps]. In acromegaly, the calculated relative risk for all SB lesions was 1.69 [95%confidence interval (CI): 0.78-3.65], while the relative risk for SB polyps was 2.50 (95% CI: 1.23-5.07). The effective duration of active disease was longer in patients with positive than in those with negative VCE (112+/-89 vs 49+/-40 months, p=0.06). In conclusion, these preliminary results suggest that acromegalic patients might have a high risk of SB polyp development. VCE might be a useful adjunctive diagnostic tool in acromegaly.

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalJournal of Endocrinological Investigation
Volume32
Issue number6
Publication statusPublished - Jun 2009

Fingerprint

Acromegaly
Endoscopy
Polyps
Neoplasms
Gastrointestinal Stromal Tumors
Confidence Intervals
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor II
Colonoscopy
Tumor Biomarkers
Insulin-Like Growth Factor I
Epidemiologic Studies
Colon
Radiotherapy
Pharmacology
Control Groups
Population

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Detection of small bowel tumors by videocapsule endoscopy in patients with acromegaly. / Ronchi, C. L.; Coletti, F.; Fesce, E.; Montefusco, L.; Ogliari, C.; Verrua, E.; Epaminonda, P.; Ferrante, E.; Malchiodi, E.; Morelli, V.; Beck-Peccoz, P.; Arosio, M.

In: Journal of Endocrinological Investigation, Vol. 32, No. 6, 06.2009, p. 495-500.

Research output: Contribution to journalArticle

Ronchi, CL, Coletti, F, Fesce, E, Montefusco, L, Ogliari, C, Verrua, E, Epaminonda, P, Ferrante, E, Malchiodi, E, Morelli, V, Beck-Peccoz, P & Arosio, M 2009, 'Detection of small bowel tumors by videocapsule endoscopy in patients with acromegaly.', Journal of Endocrinological Investigation, vol. 32, no. 6, pp. 495-500.
Ronchi, C. L. ; Coletti, F. ; Fesce, E. ; Montefusco, L. ; Ogliari, C. ; Verrua, E. ; Epaminonda, P. ; Ferrante, E. ; Malchiodi, E. ; Morelli, V. ; Beck-Peccoz, P. ; Arosio, M. / Detection of small bowel tumors by videocapsule endoscopy in patients with acromegaly. In: Journal of Endocrinological Investigation. 2009 ; Vol. 32, No. 6. pp. 495-500.
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abstract = "The prevalence of colon polyposis andmalignancies is increased in acromegalic patients as compared to the general population. An epidemiological study suggests a high prevalence also of small bowel (SB) tumors that nowadays may be detected by videocapsule endoscopy (VCE). The aim of the study was to assess the prevalence of SB neoplasms using VCE in acromegalic patients in comparison to control subjects and to correlate it with cancer risk factors and acromegaly-related parameters. Eighteen acromegalic patients (6 males and 12 females, age+/-SD: 54+/-10 yr), 5 cured after surgery (followed by radiotherapy in 3 cases) and 13 on pharmacological treatment were enrolled, and 36 sex- and age-matched non-acromegalic subjects served as a control group. Cancer risk factors, duration of acromegaly, GH and IGF-I levels, IGF binding protein 3 and IGF-II concentrations, metabolic parameters, tumor markers, colonic lesions by total colonoscopy, and SB lesions by VCE were investigated. VCE images suggestive of SB lesions were detected in 5/36 controls [14{\%}, 4 described as gastrointestinal stromal nodular tumors (GIST), and 1 as polyp] and in 5/18 acromegalic patients [28{\%}, 2 GIST and 3 polyps]. In acromegaly, the calculated relative risk for all SB lesions was 1.69 [95{\%}confidence interval (CI): 0.78-3.65], while the relative risk for SB polyps was 2.50 (95{\%} CI: 1.23-5.07). The effective duration of active disease was longer in patients with positive than in those with negative VCE (112+/-89 vs 49+/-40 months, p=0.06). In conclusion, these preliminary results suggest that acromegalic patients might have a high risk of SB polyp development. VCE might be a useful adjunctive diagnostic tool in acromegaly.",
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AU - Ogliari, C.

AU - Verrua, E.

AU - Epaminonda, P.

AU - Ferrante, E.

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AU - Morelli, V.

AU - Beck-Peccoz, P.

AU - Arosio, M.

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