L'USO DI ANTICORPI MONOCLONALI CHE RICONOSCONO LA NEURAL CELL ADHESION MOLECULE (NCAM) NELLA DIAGNOSI DELL LOCALIZZAZIONI MIDOLLARI DI MICROCITOMA POLMONARE

Translated title of the contribution: Detection of small cell lung cancer localization in bone marrow aspirates by monoclonal antibodies directed against the neural cell adhesion molecule (NCAM)

F. Pasini, G. Pelosi, A. Santo, M. Zaninelli, R. Mostacci, A. Masotti, P. Spagnolli, E. Recaldin, G. L. Cetto

Research output: Contribution to journalArticlepeer-review

Abstract

We have used immunocytochemistry to identify tumor cells in bone-marrow aspirates of 40 untreated patients with small cell lung cancer and we compared the results with conventional histomorphology. The monoclonal antibodies (MAbs) used were NCC-LU-243 and NCC-LU-246 (both cluster 1). For each MAb 76 slides were evaluated. Sixty bone-marrow biopsies were also obtained from these patients. The positivity rate between the 2 MAbs was not statistically different (46% for NCC-LU-246 and 43% for NCC-LU-243). Bone-marrow biopsies detected tumor localization in 8/60 specimens (13%), significantly less than immunocytochemistry with anti-NCAM MAbs (p = 0.003). Moreover, bone-marrow aspirates were positive for cluster 1 antigen in 6/16 patients with limited disease at diagnosis. The results confirm that NCC-LU-243 and NCC-LU-246 have equivalent ability to identify bone-marrow involvement; immunocytochemistry appears to be better suited for this purpose than conventional bone-marrow biopsy; a non-negligible proportion of patients with 'limited disease' might be understaged; the clinical value of detecting bone marrow involvement by immnnocytochemistry is still unclear.

Translated title of the contributionDetection of small cell lung cancer localization in bone marrow aspirates by monoclonal antibodies directed against the neural cell adhesion molecule (NCAM)
Original languageItalian
Pages (from-to)433-438
Number of pages6
JournalMinerva Medica
Volume85
Issue number9
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Medicine(all)

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