Detection of stable and defined predictors in human renal carcinoma

M. D'Armiento, R. Damiano, M. D'Acquisto, S. Pepe, A. Ruggiero, M. De Laurentiis, S. Staibano, G. De Rosa

Research output: Contribution to journalArticle

Abstract

To evaluate the grade of heterogeneicity of nuclear DNA- content and intratumoural expression of p53 and bcl2 expression in human renal cell carcinoma (RCC), nuclear DNA- content, p53 and bcl-2 proteins expression in 296 samples of renal cell carcinoma were related to survival in 32 operable patients. The expression of p53 and bcl-2 proteins was studied by immunochemistry, and DNA content by flow cytometry. Mean follow up was 26.25 months (SD 12.08, range 1-43). Heterogeneous DNA content was detected in 21/32 (65.6%) tumours and correlated with more advanced Robson stage (p=0.04) and, nearly significant, larger tumour size (p=0.06). Intratumour heterogeneity was also detected for p53 and bcl-2 protein overexpression. A high level of p53 expressions correlated with low levels of bcl-2 gene product (p=0.008), aneuploidy (p

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalActa Urologica Italica
Volume12
Issue number2
Publication statusPublished - 1998

    Fingerprint

Keywords

  • Prognostic factors
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

D'Armiento, M., Damiano, R., D'Acquisto, M., Pepe, S., Ruggiero, A., De Laurentiis, M., Staibano, S., & De Rosa, G. (1998). Detection of stable and defined predictors in human renal carcinoma. Acta Urologica Italica, 12(2), 67-73.