Abstract
We have studied motor, somatosensory, brainstem auditory and visual evoked potentials in two patients with ML III without overt neurollogic symptoms. Both our patients showed abnormal central motor fuctions upon magnetic cortical stimulation; in addition, in one of them, we observed a decreased conduction velocity of the nervous impulse in the central tract of the upper limb somatosensory pathway, from the cervical spinal cord to sensory cortex. Our results suggest that central motor pathways are affected in both children and also that the central somatosensory system is involved in one of them. We propose that the electrophysiological techniques might be of help to detect, locate and monitor minimal neurological lesions of mild lysosomal disorders like ML III.
| Original language | English |
|---|---|
| Pages (from-to) | 40-42 |
| Number of pages | 3 |
| Journal | Neuropediatrics |
| Volume | 29 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 1998 |
Fingerprint
Keywords
- Evoked potentials
- Lysosomal disease
- Mucolipidosis III
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology
Cite this
Detection of subclinical central nervous system abnormalities in two patients with mucolipidosis III by the use of motor and somatosensory evoked potentials. / Toscano, E.; Perretti, Anna; Balbi, P.; Silvestro, Eufrasia; Andria, G.; Parenti, G.
In: Neuropediatrics, Vol. 29, No. 1, 02.1998, p. 40-42.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Detection of subclinical central nervous system abnormalities in two patients with mucolipidosis III by the use of motor and somatosensory evoked potentials
AU - Toscano, E.
AU - Perretti, Anna
AU - Balbi, P.
AU - Silvestro, Eufrasia
AU - Andria, G.
AU - Parenti, G.
PY - 1998/2
Y1 - 1998/2
N2 - We have studied motor, somatosensory, brainstem auditory and visual evoked potentials in two patients with ML III without overt neurollogic symptoms. Both our patients showed abnormal central motor fuctions upon magnetic cortical stimulation; in addition, in one of them, we observed a decreased conduction velocity of the nervous impulse in the central tract of the upper limb somatosensory pathway, from the cervical spinal cord to sensory cortex. Our results suggest that central motor pathways are affected in both children and also that the central somatosensory system is involved in one of them. We propose that the electrophysiological techniques might be of help to detect, locate and monitor minimal neurological lesions of mild lysosomal disorders like ML III.
AB - We have studied motor, somatosensory, brainstem auditory and visual evoked potentials in two patients with ML III without overt neurollogic symptoms. Both our patients showed abnormal central motor fuctions upon magnetic cortical stimulation; in addition, in one of them, we observed a decreased conduction velocity of the nervous impulse in the central tract of the upper limb somatosensory pathway, from the cervical spinal cord to sensory cortex. Our results suggest that central motor pathways are affected in both children and also that the central somatosensory system is involved in one of them. We propose that the electrophysiological techniques might be of help to detect, locate and monitor minimal neurological lesions of mild lysosomal disorders like ML III.
KW - Evoked potentials
KW - Lysosomal disease
KW - Mucolipidosis III
UR - http://www.scopus.com/inward/record.url?scp=0031888698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031888698&partnerID=8YFLogxK
U2 - 10.1055/s-2007-973532
DO - 10.1055/s-2007-973532
M3 - Article
VL - 29
SP - 40
EP - 42
JO - Neuropediatrics
JF - Neuropediatrics
SN - 0174-304X
IS - 1
ER -