Detection of the prethrombotic state due to procoagulant imbalance

P. M. Mannucci, P. L F Giangrande

Research output: Contribution to journalArticlepeer-review

Abstract

We have reviewed the laboratory methods used to diagnose the prethrombotic state, defined as a procoagulant imbalance between the production and inhibition of enzyme activity in the coagulation pathway short of fibrin deposition. One diagnostic approach is that of measuring the plasma levels of activation peptides which are released from the zymogens of the coagulation cascade when they are activated. Another approach is that of measuring the plasma levels of complexes formed in plasma when enzymes of the coagulation cascade are neutralized by their naturally-occuring inhibitors such as thrombin-antithrombin complex. The clinical usefulness of these methods still needs to be defined with prospective studies.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalEuropean Journal of Haematology
Volume48
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Hematology

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