Detection of trisomy 12 on ovarian sex cord stromal tumors by fluorescence in situ hybridization

Domenica Taruscio, Maria Luisa Carcangiu, David C. Ward

Research output: Contribution to journalArticlepeer-review


Trisomy of chromosome 12 has been frequently described in various neoplasms, particularly in tumors of the female genitourinary tract. Fluorescence in situ hybridization with a centromeric repetitive DNA probe, specific for chromosome 12, was done to detect such cytogenic changes on frozen-tissue sections from 10 cases of ovarian sex cord stromal tumors. The case series was composed by granulosa cell tumors (four cases), fibromas (four cases), thecoma (one case), and Sertoli-Leydig cell tumor (one case). In granulosa cell tumors, the range of trisomy was 12 to 32% and in fibromas 8 to 22%, whereas in the single case of thecoma trisomy was present in 8% and in the Sertoli-Leydig cell tumor in 4% of the nuclei examined. These results represent an additional series of cases of trisomy 12 in ovarian neoplasms, namely, in ovarian sex cord stromal tumors.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalDiagnostic Molecular Pathology
Issue number1
Publication statusPublished - 1993


  • Fluorescence in situ hybridization
  • Ovary tumors
  • Sex cord stromal tumors
  • Trisomy 12

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine


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