Detection rate, pattern of relapse and influence on therapeutic decision of PSMA PET/CT in patients affected by biochemical recurrence after radical prostatectomy, a retrospective case series

G. Francolini, B. Detti, M. Bottero, T. Zilli, A. Lancia, A. Bruni, S. Borghesi, M. Mariotti, P. Castellucci, S. Fanti, A. R. Filippi, M. A. Teriaca, V. Maragna, C. Aristei, E. Mazzeo, L. Livi, G. Ingrosso

Research output: Contribution to journalArticle

Abstract

Aims: 68Ga-Prostate-specific membrane antigen (PSMA) PET/CT is widely used in patients with biochemical recurrence (BCR) after radical prostatectomy. We collected data about patients staged with PSMA PET/CT after BCR (PSA < 1 ng/ml) in four different institutes. Impact of baseline features (Gleason score, risk classification, PSA at recurrence, PSA doubling time and time to recurrence) was explored to understand predictive factors of (PSMA) PET/CT positivity. Impact of restaging on following treatment approaches was reported. Results: 92 patients were included. PSMA PET/CT detection rate was 56.5% and low-volume disease (≤ 3 non-visceral lesions) was detected in 52.2% of patients. After positive scan, 13.5% of patients still lies on observation, ADT alone was administered in 30.8% of cases, Stereotactic body RT (SBRT) alone was delivered to 44.2% of patients and 11.5% of patients underwent concomitant SBRT and ADT. Seven patients underwent conventional salvage prostate bed RT. Chi-squared test showed a higher rate of positive PSMA PET/CT for patients with Gleason score > 7 (p = 0.004) and TTR < 29.5 months (p = 0.003). Conclusions: PSMA PET/CT showed a high detection rate. This influenced clinical management in a significant percentage of patients, allowing treatment tailoring on the basis of imaging.

Original languageEnglish
JournalClinical and Translational Oncology
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Biochemical recurrence
  • Prostate cancer
  • PSMA PET
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Francolini, G., Detti, B., Bottero, M., Zilli, T., Lancia, A., Bruni, A., Borghesi, S., Mariotti, M., Castellucci, P., Fanti, S., Filippi, A. R., Teriaca, M. A., Maragna, V., Aristei, C., Mazzeo, E., Livi, L., & Ingrosso, G. (Accepted/In press). Detection rate, pattern of relapse and influence on therapeutic decision of PSMA PET/CT in patients affected by biochemical recurrence after radical prostatectomy, a retrospective case series. Clinical and Translational Oncology. https://doi.org/10.1007/s12094-020-02427-2