AIMS: 68Ga-Prostate-specific membrane antigen (PSMA) PET/CT is widely used in patients with biochemical recurrence (BCR) after radical prostatectomy. We collected data about patients staged with PSMA PET/CT after BCR (PSA < 1 ng/ml) in four different institutes. Impact of baseline features (Gleason score, risk classification, PSA at recurrence, PSA doubling time and time to recurrence) was explored to understand predictive factors of (PSMA) PET/CT positivity. Impact of restaging on following treatment approaches was reported.
RESULTS: 92 patients were included. PSMA PET/CT detection rate was 56.5% and low-volume disease (≤ 3 non-visceral lesions) was detected in 52.2% of patients. After positive scan, 13.5% of patients still lies on observation, ADT alone was administered in 30.8% of cases, Stereotactic body RT (SBRT) alone was delivered to 44.2% of patients and 11.5% of patients underwent concomitant SBRT and ADT. Seven patients underwent conventional salvage prostate bed RT. Chi-squared test showed a higher rate of positive PSMA PET/CT for patients with Gleason score > 7 (p = 0.004) and TTR < 29.5 months (p = 0.003).
CONCLUSIONS: PSMA PET/CT showed a high detection rate. This influenced clinical management in a significant percentage of patients, allowing treatment tailoring on the basis of imaging.
|Number of pages||8|
|Journal||Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico|
|Publication status||Published - Feb 2021|
- Androgen Antagonists/therapeutic use
- Antigens, Surface
- Gallium Isotopes
- Gallium Radioisotopes
- Glutamate Carboxypeptidase II
- Middle Aged
- Neoplasm Grading
- Neoplasm Recurrence, Local/blood
- Neoplasm Staging/methods
- Positron Emission Tomography Computed Tomography
- Prostate-Specific Antigen/blood
- Prostatic Neoplasms/blood
- Radiosurgery/statistics & numerical data
- Radiotherapy/statistics & numerical data
- Radiotherapy, Intensity-Modulated/statistics & numerical data
- Retrospective Studies
- Salvage Therapy/methods
- Time Factors