Determinants and clinical significance of natriuretic peptides in hypertrophic cardiomyopathy

C. Briguori, Sandro Betocchi, F. Manganelli, B. Gigante, M. A. Losi, Q. Ciampi, R. Gottilla, A. Violante, C. G. Tocchetti, M. Volpe, M. Chiariello

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Atrial and brain natriuretic peptide levels closely reflect impaired left ventricular function in patients with heart failure. In the present study we assessed the determinants and the clinical significance of atrial and brain natriuretic peptide plasma levels in hypertrophic cardiomyopathy. Methods and Results: In 44 patients with hypertrophic cardiomyopathy (40 ± 15 years) we evaluated: (a) atrial and brain natriuretic peptide plasma levels; (b) left ventricular hypertrophy; (c) left ventricular ejection fraction; (d) transmitral and pulmonary venous flow velocity patterns, and left atrial fractional shortening; (e) left ventricular outflow tract gradient; (f) maximal oxygen consumption. Left ventricular hypertrophy influenced only brain natriuretic peptide levels (r=0.32; P

Original languageEnglish
Pages (from-to)1328-1336
Number of pages9
JournalEuropean Heart Journal
Volume22
Issue number15
DOIs
Publication statusPublished - 2001

Keywords

  • Cardiomyopathy
  • Diastole
  • Hypertrophy
  • Natriuretic peptide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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