Abstract
Objective: Osteoporosis (OP) and increased risk of fracture are relevant features in patients with rheumatoid arthritis (RA). Low levels of serum vitamin D are frequently reported and correlate with a higher RA activity. This study evaluated factors related with the prescription of vitamin D supplements in RA patients and variables influencing the achievement of adequate vitamin D levels. Methods: Study population was made up by 1168 consecutive RA patients from 22 Italian rheumatology centers. Demographic and clinical variables data were collected and 250H serum vitamin D was measured in all patients. Insufficient serum 250H vitamin D levels were defined as values lower than 20 ng/mL. Results: The majority of patients (56.0%) was not taking vitamin D supplements. Among the 514 supplemented patients, 196 (38.1%) were taking insufficient dosages (≤440 IU/day). Variables related with the prescription of supplements were older age, female sex, previous bone density assessment and OP diagnosis. Among the 318 patients using daily supplements ≥800 IU, 88 patients (27.7%) did not reach adequate levels of vitamin D. In these patients a higher HAQ score (OR for 1 point=1.62, 95% CI: 1.06-2.49; p=0.03) and poor sun exposure (OR=238, 95% CI: 1.05-5.55; p=0..04) were predictors of vitamin D insufficiency. Conclusion: Vitamin D deficiency is common in patients with RA, even in patients who are regularly using supplements. Vitamin D supplementation is often ineffective even at the recommended dose of 800 IU/day in more disabled patients.
| Original language | English |
|---|---|
| Pages (from-to) | 714-719 |
| Number of pages | 6 |
| Journal | Clinical and Experimental Rheumatology |
| Volume | 30 |
| Issue number | 5 |
| Publication status | Published - 2012 |
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Keywords
- Drug therapy
- Epidemiology
- Osteoporosis
- Rheumatoid arthritis
- Vitamin D
ASJC Scopus subject areas
- Rheumatology
- Immunology
- Immunology and Allergy
Cite this
Determinants and effects of vitamin D supplementation on serum 25-hydroxy-vitamin D levels in patients with rheumatoid arthritis. / Varenna, M.; Manara, M.; Cantatore, F. P.; Del Puente, A.; Di Munno, O.; Malavolta, N.; Minisola, G.; Adami, S.; Sinigaglia, L.; Rossini, M.
In: Clinical and Experimental Rheumatology, Vol. 30, No. 5, 2012, p. 714-719.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Determinants and effects of vitamin D supplementation on serum 25-hydroxy-vitamin D levels in patients with rheumatoid arthritis
AU - Varenna, M.
AU - Manara, M.
AU - Cantatore, F. P.
AU - Del Puente, A.
AU - Di Munno, O.
AU - Malavolta, N.
AU - Minisola, G.
AU - Adami, S.
AU - Sinigaglia, L.
AU - Rossini, M.
PY - 2012
Y1 - 2012
N2 - Objective: Osteoporosis (OP) and increased risk of fracture are relevant features in patients with rheumatoid arthritis (RA). Low levels of serum vitamin D are frequently reported and correlate with a higher RA activity. This study evaluated factors related with the prescription of vitamin D supplements in RA patients and variables influencing the achievement of adequate vitamin D levels. Methods: Study population was made up by 1168 consecutive RA patients from 22 Italian rheumatology centers. Demographic and clinical variables data were collected and 250H serum vitamin D was measured in all patients. Insufficient serum 250H vitamin D levels were defined as values lower than 20 ng/mL. Results: The majority of patients (56.0%) was not taking vitamin D supplements. Among the 514 supplemented patients, 196 (38.1%) were taking insufficient dosages (≤440 IU/day). Variables related with the prescription of supplements were older age, female sex, previous bone density assessment and OP diagnosis. Among the 318 patients using daily supplements ≥800 IU, 88 patients (27.7%) did not reach adequate levels of vitamin D. In these patients a higher HAQ score (OR for 1 point=1.62, 95% CI: 1.06-2.49; p=0.03) and poor sun exposure (OR=238, 95% CI: 1.05-5.55; p=0..04) were predictors of vitamin D insufficiency. Conclusion: Vitamin D deficiency is common in patients with RA, even in patients who are regularly using supplements. Vitamin D supplementation is often ineffective even at the recommended dose of 800 IU/day in more disabled patients.
AB - Objective: Osteoporosis (OP) and increased risk of fracture are relevant features in patients with rheumatoid arthritis (RA). Low levels of serum vitamin D are frequently reported and correlate with a higher RA activity. This study evaluated factors related with the prescription of vitamin D supplements in RA patients and variables influencing the achievement of adequate vitamin D levels. Methods: Study population was made up by 1168 consecutive RA patients from 22 Italian rheumatology centers. Demographic and clinical variables data were collected and 250H serum vitamin D was measured in all patients. Insufficient serum 250H vitamin D levels were defined as values lower than 20 ng/mL. Results: The majority of patients (56.0%) was not taking vitamin D supplements. Among the 514 supplemented patients, 196 (38.1%) were taking insufficient dosages (≤440 IU/day). Variables related with the prescription of supplements were older age, female sex, previous bone density assessment and OP diagnosis. Among the 318 patients using daily supplements ≥800 IU, 88 patients (27.7%) did not reach adequate levels of vitamin D. In these patients a higher HAQ score (OR for 1 point=1.62, 95% CI: 1.06-2.49; p=0.03) and poor sun exposure (OR=238, 95% CI: 1.05-5.55; p=0..04) were predictors of vitamin D insufficiency. Conclusion: Vitamin D deficiency is common in patients with RA, even in patients who are regularly using supplements. Vitamin D supplementation is often ineffective even at the recommended dose of 800 IU/day in more disabled patients.
KW - Drug therapy
KW - Epidemiology
KW - Osteoporosis
KW - Rheumatoid arthritis
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84870266602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870266602&partnerID=8YFLogxK
M3 - Article
C2 - 22766134
AN - SCOPUS:84870266602
VL - 30
SP - 714
EP - 719
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 5
ER -