Determinants of bone mineral density and calcium excretion in idiopathic hypercalciuria

Giuseppe Vezzoli, P. Cravedi, D. Adamo, G. Moro, A. Rubinacci, Laura Soldati

Research output: Contribution to journalArticlepeer-review


Background. Alterations of enteral and tubular Ca handling, bone mineral density (BMD) and erythrocyte membrane (Ca-Mg)ATPase have been observed in idiopathic hypercalciuria. In the present study factors affecting BMD were analysed in hypercalciuric patients. Methods. Results in 116 hypercalciuric and 109 normocalciuric idiopathic Ca stone formers were compared. Na, Ca and phosphate excretion were measured. BMD was analysed by DEXA at lumbar-spine and femoral sites. (Ca-Mg)ATPase activity was determined by coupled enzyme assay in erythrocytes. Enteral Ca absorption and tubular reabsorption were assessed using Sr oral load test in 98 hypercalciuric and 62 normocalciuric patients. Results. Lumbar-spine BMD z-score was lower in hypercalciuric than normocalciuric patients (-1.05±0.118 vs -0.65±0.114; p-1·min-1; p

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalItalian Journal of Mineral and Electrolyte Metabolism
Issue number1-4
Publication statusPublished - 2001


  • Bone density
  • Bone diseases, metabolic
  • Ca2+ Mg2+ ATPase
  • Cacium, urine
  • Intestinal absorption
  • Kidney calculi
  • Sodium, metabolism

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology


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