The alterations in glucose homeostasis in the early phase of nondiabetic ST-elevation myocardial infarction (STEMI) are complex, involving not only hyperglycemia but also the development of acute insulin resistance (as part of the stress response) as assessed by the Homeostatic Model Assessment index (HOMA). No data is so far available on C-peptide values in the acute phase of STEMI in patients without previously known diabetes.The aims of the present investigation, performed in 782 consecutive STEMI patients without previously known diabetes, were as follows: a) to assess the determinants of C-peptide levels; b) to address the relation between acute insulin-resistance and Killip class; and c) to investigate the prognostic role of C-peptide for early mortality.In our series, 729 patients (93.2%) were in Killip I-II (group A), while 53 patients (6.8%) were in Killip classes III-IV (group B). Group B showed higher levels of admission glycemia, insulin and C-peptide (p.
- Acute insulin resistance
- ST-elevation myocardial infarction
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Cardiology and Cardiovascular Medicine
- Physiology (medical)