Determinants of C-peptide levels and acute insulin resistance/sensitivity in nondiabetic STEMI role of Killip class

Chiara Lazzeri, Serafina Valente, Maria Grazia D'Alfonso, Marco Chiostri, Gian Franco Gensini

Research output: Contribution to journalArticle

Abstract

The alterations in glucose homeostasis in the early phase of nondiabetic ST-elevation myocardial infarction (STEMI) are complex, involving not only hyperglycemia but also the development of acute insulin resistance (as part of the stress response) as assessed by the Homeostatic Model Assessment index (HOMA). No data is so far available on C-peptide values in the acute phase of STEMI in patients without previously known diabetes.The aims of the present investigation, performed in 782 consecutive STEMI patients without previously known diabetes, were as follows: a) to assess the determinants of C-peptide levels; b) to address the relation between acute insulin-resistance and Killip class; and c) to investigate the prognostic role of C-peptide for early mortality.In our series, 729 patients (93.2%) were in Killip I-II (group A), while 53 patients (6.8%) were in Killip classes III-IV (group B). Group B showed higher levels of admission glycemia, insulin and C-peptide (p.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalIJC Metabolic and Endocrine
Volume2
DOIs
Publication statusPublished - 2014

Keywords

  • Acute insulin resistance
  • C-Peptide
  • Insulin
  • Nondiabetic
  • Prognosis
  • ST-elevation myocardial infarction

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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