Determinants of disability in multiple sclerosis at various disease stages: A multiparametric magnetic resonance study

Annalisa Pulizzi, Marco Rovaris, Elda Judica, Maria Pia Sormani, Vittorio Martinelli, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journalArticlepeer-review


Objective: To investigate whether diffusion-tensor magnetic resonance imaging and whole brain N-acetylaspartate (WBNAA) proton magnetic resonance spectroscopy can provide complementary pieces of information to achieve a better understanding of the factors associated with disability in multiple sclerosis (MS). Design: Cross-sectional survey. Setting: Referral hospital-based MS center. Patients: Ten healthy control subjects, 27 patients with a clinically isolated neurological syndrome, 21 patients with relapsing-remitting MS, and 29 patients with secondary progressive MS. Main Outcome Measures: Conventional and diffusion-tensor magnetic resonance imaging, as well as WBNAA proton magnetic resonance spectroscopy, of the brain was performed. T2-hyperintense lesion volumes were measured. The mean values of mean diffusivity (MD) and fractional anisotropy of T2-visible lesions were computed. Histograms of MD and fractional anisotropy values were produced for normal-appearing white matter and gray matter (GM). Results: Patients with a clinically isolated neurological syndrome had a significantly (P=.002) lower WBNAA concentration than control subjects. Patients with relapsing-remitting MS had significantly higher T2 lesion volume (P=.007), mean lesion MD (P=.003), normal-appearing white matter fractional anisotropy peak height (P=.03), and a lower WBNAA concentration (P

Original languageEnglish
Pages (from-to)1163-1168
Number of pages6
JournalArchives of Neurology
Issue number8
Publication statusPublished - Aug 2007

ASJC Scopus subject areas

  • Neuroscience(all)


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