Determinants of disability in multiple sclerosis at various disease stages

A multiparametric magnetic resonance study

Annalisa Pulizzi, Marco Rovaris, Elda Judica, Maria Pia Sormani, Vittorio Martinelli, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objective: To investigate whether diffusion-tensor magnetic resonance imaging and whole brain N-acetylaspartate (WBNAA) proton magnetic resonance spectroscopy can provide complementary pieces of information to achieve a better understanding of the factors associated with disability in multiple sclerosis (MS). Design: Cross-sectional survey. Setting: Referral hospital-based MS center. Patients: Ten healthy control subjects, 27 patients with a clinically isolated neurological syndrome, 21 patients with relapsing-remitting MS, and 29 patients with secondary progressive MS. Main Outcome Measures: Conventional and diffusion-tensor magnetic resonance imaging, as well as WBNAA proton magnetic resonance spectroscopy, of the brain was performed. T2-hyperintense lesion volumes were measured. The mean values of mean diffusivity (MD) and fractional anisotropy of T2-visible lesions were computed. Histograms of MD and fractional anisotropy values were produced for normal-appearing white matter and gray matter (GM). Results: Patients with a clinically isolated neurological syndrome had a significantly (P=.002) lower WBNAA concentration than control subjects. Patients with relapsing-remitting MS had significantly higher T2 lesion volume (P=.007), mean lesion MD (P=.003), normal-appearing white matter fractional anisotropy peak height (P=.03), and a lower WBNAA concentration (P

Original languageEnglish
Pages (from-to)1163-1168
Number of pages6
JournalArchives of Neurology
Volume64
Issue number8
DOIs
Publication statusPublished - Aug 2007

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Multiple Sclerosis
Magnetic Resonance Spectroscopy
Anisotropy
Brain
Relapsing-Remitting Multiple Sclerosis
Diffusion Magnetic Resonance Imaging
Chronic Progressive Multiple Sclerosis
Healthy Volunteers
Referral and Consultation
Cross-Sectional Studies
Outcome Assessment (Health Care)
N-acetylaspartate
Lesion
White Matter
Proton Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Syndrome
Spectroscopy
Appearings

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Determinants of disability in multiple sclerosis at various disease stages : A multiparametric magnetic resonance study. / Pulizzi, Annalisa; Rovaris, Marco; Judica, Elda; Sormani, Maria Pia; Martinelli, Vittorio; Comi, Giancarlo; Filippi, Massimo.

In: Archives of Neurology, Vol. 64, No. 8, 08.2007, p. 1163-1168.

Research output: Contribution to journalArticle

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