Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

the Swiss HIV Cohort Study

doi:10.1038/s41467-019-10884-9

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

the Swiss HIV Cohort Study

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article

Abstract

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.

Original language	English
Article number	3193
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-10884-9
Publication status	Published - Dec 1 2019

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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the Swiss HIV Cohort Study (2019). Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART. Nature Communications, 10(1), [3193]. https://doi.org/10.1038/s41467-019-10884-9

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title = "Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART",

abstract = "The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.",

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AU - Bachmann, Nadine

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AU - Vongrad, Valentina

AU - Turk, Teja

AU - Neumann, Kathrin

AU - Beerenwinkel, Niko

AU - Bogojeska, Jasmina

AU - Fellay, Jaques

AU - Roth, Volker

AU - Kok, Yik Lim

AU - Thorball, Christian W.

AU - Borghesi, Alessandro

AU - Parbhoo, Sonali

AU - Wieser, Mario

AU - Böni, Jürg

AU - Perreau, Matthieu

AU - Klimkait, Thomas

AU - Yerly, Sabine

AU - Battegay, Manuel

AU - Rauch, Andri

AU - Hoffmann, Matthias

AU - Bernasconi, Enos

AU - Cavassini, Matthias

AU - Kouyos, Roger D.

AU - Günthard, Huldrych F.

AU - Metzner, Karin J.

AU - Anagnostopoulos, Alexia

AU - Battegay, Manuel

AU - Bernasconi, Enos

AU - Böni, Jürg

AU - Braun, Dominique L.

AU - Bucher, Heiner C.

AU - Calmy, Alexandra

AU - Cavassini, Matthias

AU - Ciuffi, Angela

AU - Dollenmaier, Günter

AU - Egger, Matthias

AU - Elzi, Luigia

AU - Fehr, Jan

AU - Fellay, Jacques

AU - Furrer, Hansjakob

AU - Fux, Christoph A.

AU - Günthard, Huldrych F.

AU - Haerry, David

AU - Hasse, Barbara

AU - Hirsch, Hans H.

AU - Hoffmann, Matthias

AU - Hösli, Irene

AU - Huber, Michael

AU - Kahlert, Christian

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N2 - The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.

AB - The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.

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