TY - JOUR
T1 - Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
AU - the Swiss HIV Cohort Study
AU - Bachmann, Nadine
AU - von Siebenthal, Chantal
AU - Vongrad, Valentina
AU - Turk, Teja
AU - Neumann, Kathrin
AU - Beerenwinkel, Niko
AU - Bogojeska, Jasmina
AU - Fellay, Jaques
AU - Roth, Volker
AU - Kok, Yik Lim
AU - Thorball, Christian W.
AU - Borghesi, Alessandro
AU - Parbhoo, Sonali
AU - Wieser, Mario
AU - Böni, Jürg
AU - Perreau, Matthieu
AU - Klimkait, Thomas
AU - Yerly, Sabine
AU - Battegay, Manuel
AU - Rauch, Andri
AU - Hoffmann, Matthias
AU - Bernasconi, Enos
AU - Cavassini, Matthias
AU - Kouyos, Roger D.
AU - Günthard, Huldrych F.
AU - Metzner, Karin J.
AU - Anagnostopoulos, Alexia
AU - Battegay, Manuel
AU - Bernasconi, Enos
AU - Böni, Jürg
AU - Braun, Dominique L.
AU - Bucher, Heiner C.
AU - Calmy, Alexandra
AU - Cavassini, Matthias
AU - Ciuffi, Angela
AU - Dollenmaier, Günter
AU - Egger, Matthias
AU - Elzi, Luigia
AU - Fehr, Jan
AU - Fellay, Jacques
AU - Furrer, Hansjakob
AU - Fux, Christoph A.
AU - Günthard, Huldrych F.
AU - Haerry, David
AU - Hasse, Barbara
AU - Hirsch, Hans H.
AU - Hoffmann, Matthias
AU - Hösli, Irene
AU - Huber, Michael
AU - Kahlert, Christian
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.
AB - The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.
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U2 - 10.1038/s41467-019-10884-9
DO - 10.1038/s41467-019-10884-9
M3 - Article
AN - SCOPUS:85069450254
VL - 10
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 3193
ER -