Determinants of homocysteine levels in colorectal and breast cancer patients

Patrizia Ferroni, R. Palmirotta, F. Martini, S. Riondino, A. Savonarola, A. Spila, F. Ciatti, V. Sini, S. Mariotti, G. Del Monte, M. Roselli, F. Guadagni

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Homocysteinemia has been associated with oncogenic risk. This study was designed to investigate the homocysteine (Hcy) genotypelphenotype interactions together with the inflammatory and nutritional status of cancer patients. Patients and Methods: The Hcy levels were analyzed in 47 cancer patients in association with methylenetetrahydrofolate reductase (MTHFR) polymorphisms, folate and inflammatory markers. Results: The MTHFR C677T and A1298C genotype distributions did not differ from those predicted by the Hardy-Weinberg distribution. Conversely, the Hcy levels were higher in the cancer patients (p=0.04), who were also characterized by low-grade inflammation. The Hcy levels correlated with the interleukin-6 (IL-6) (p=0.001), tumor necrosis factor-a (TNF-a) (p=0.042) and folate (p

Original languageEnglish
Pages (from-to)4131-4138
Number of pages8
JournalAnticancer Research
Volume29
Issue number10
Publication statusPublished - Oct 2009

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Homocysteine
Colorectal Neoplasms
Breast Neoplasms
Methylenetetrahydrofolate Reductase (NADPH2)
Folic Acid
Neoplasms
Nutritional Status
Interleukin-6
Tumor Necrosis Factor-alpha
Genotype
Inflammation

Keywords

  • Breast cancer
  • Colorectal cancer
  • Homocysteinemia
  • Inflammation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Determinants of homocysteine levels in colorectal and breast cancer patients. / Ferroni, Patrizia; Palmirotta, R.; Martini, F.; Riondino, S.; Savonarola, A.; Spila, A.; Ciatti, F.; Sini, V.; Mariotti, S.; Del Monte, G.; Roselli, M.; Guadagni, F.

In: Anticancer Research, Vol. 29, No. 10, 10.2009, p. 4131-4138.

Research output: Contribution to journalArticle

Ferroni, P, Palmirotta, R, Martini, F, Riondino, S, Savonarola, A, Spila, A, Ciatti, F, Sini, V, Mariotti, S, Del Monte, G, Roselli, M & Guadagni, F 2009, 'Determinants of homocysteine levels in colorectal and breast cancer patients', Anticancer Research, vol. 29, no. 10, pp. 4131-4138.
Ferroni, Patrizia ; Palmirotta, R. ; Martini, F. ; Riondino, S. ; Savonarola, A. ; Spila, A. ; Ciatti, F. ; Sini, V. ; Mariotti, S. ; Del Monte, G. ; Roselli, M. ; Guadagni, F. / Determinants of homocysteine levels in colorectal and breast cancer patients. In: Anticancer Research. 2009 ; Vol. 29, No. 10. pp. 4131-4138.
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