Determinantes de insuficiencia cardíaca tardía postinfarto de miocardio: Resultados del estudio GISSI Prevenzione

Translated title of the contribution: Determinants of late-onset heart failure in myocardial infarction survivors: GISSI prevenzione trial results

Alejandro Macchia, Giacomo Levantesi, Rosa M. Marfisi, Maria G. Franzosi, Aldo P. Maggioni, Gian L. Nicolosi, Carlo Schweiger, Luigi Tavassi, Gianni Tognoni, Franco Valagussa, Roberto Marchioli

Research output: Contribution to journalArticle

Abstract

Introduction and objectives. Improvement in the early phase of myocardial infarction (MI) is associated with a higher rate of late complications, including late-onset heart failure (LHF). The factors predicting LHF are not well understood. Our aims were to identify the factors predicting LHF and to determine the survival rate in these patients. Patients and method. The GISSI-Prevenzione trial involved 11 323 low-risk patients (NYHA class ≤ II) who had had a recent MI (<3 months). It was a multicenter, open-label, clinical trial of the efficacy of treatment with polyunsaturated fatty acids, vitamin E, both, or neither. Patients with heart failure at baseline and those whose ejection fraction was unknown (n = 2908) were excluded from the present analysis. Late-onset heart failure was defined prospectively as hospital admission due to heart failure. A Cox regression model adjusted for major covariates was used for risk analysis. Results. The study included 8415 patients. During 3.5 years of follow-up, 192 (2.3%) developed LHF. The risk of LHF could be predicted from readily available parameters: age (per year; RR=1.07; 95% CI, 1.05-1.09), ejection fraction (per 1% increment; RR=0.96; 95% CI, 0.94-0.97), heart rate (≥74 beats/min; RR=1.62; 95% CI, 1.21-2.16), white blood cell count (≥8900 per ml; RR=1.42; 95% CI, 1.05-1.94), diabetes (RR=1.62; 95% CI, 1.17-2.24), hypertension (RR=1.76; 95% CI, 1.33-2.34), peripheral artery disease (RR=2.1 1; 95% CI, 1.32-3.37), and reinfarction (RR=2.09; 95% CI, 1.28-3.39). LHF was associated with poor survival: (RR=2.34; 95% CI, 1.63-3.36). Conclusions. The risk of LHF in post-MI patients can be predicted from readily available parameters. LHF was associated with a poor prognosis.

Original languageSpanish
Pages (from-to)1266-1272
Number of pages7
JournalRevista Espanola de Cardiologia
Volume58
Issue number11
DOIs
Publication statusPublished - Nov 2005

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Survivors
Heart Failure
Myocardial Infarction
Peripheral Arterial Disease
Unsaturated Fatty Acids
Vitamin E
Leukocyte Count
Proportional Hazards Models
Survival Rate
Heart Rate
Clinical Trials
Hypertension
Survival

Keywords

  • Heart failure
  • Myocardial infarction
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Macchia, A., Levantesi, G., Marfisi, R. M., Franzosi, M. G., Maggioni, A. P., Nicolosi, G. L., ... Marchioli, R. (2005). Determinantes de insuficiencia cardíaca tardía postinfarto de miocardio: Resultados del estudio GISSI Prevenzione. Revista Espanola de Cardiologia, 58(11), 1266-1272. https://doi.org/10.1016/S1885-5857(06)60413-1

Determinantes de insuficiencia cardíaca tardía postinfarto de miocardio : Resultados del estudio GISSI Prevenzione. / Macchia, Alejandro; Levantesi, Giacomo; Marfisi, Rosa M.; Franzosi, Maria G.; Maggioni, Aldo P.; Nicolosi, Gian L.; Schweiger, Carlo; Tavassi, Luigi; Tognoni, Gianni; Valagussa, Franco; Marchioli, Roberto.

In: Revista Espanola de Cardiologia, Vol. 58, No. 11, 11.2005, p. 1266-1272.

Research output: Contribution to journalArticle

Macchia, A, Levantesi, G, Marfisi, RM, Franzosi, MG, Maggioni, AP, Nicolosi, GL, Schweiger, C, Tavassi, L, Tognoni, G, Valagussa, F & Marchioli, R 2005, 'Determinantes de insuficiencia cardíaca tardía postinfarto de miocardio: Resultados del estudio GISSI Prevenzione', Revista Espanola de Cardiologia, vol. 58, no. 11, pp. 1266-1272. https://doi.org/10.1016/S1885-5857(06)60413-1
Macchia, Alejandro ; Levantesi, Giacomo ; Marfisi, Rosa M. ; Franzosi, Maria G. ; Maggioni, Aldo P. ; Nicolosi, Gian L. ; Schweiger, Carlo ; Tavassi, Luigi ; Tognoni, Gianni ; Valagussa, Franco ; Marchioli, Roberto. / Determinantes de insuficiencia cardíaca tardía postinfarto de miocardio : Resultados del estudio GISSI Prevenzione. In: Revista Espanola de Cardiologia. 2005 ; Vol. 58, No. 11. pp. 1266-1272.
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abstract = "Introduction and objectives. Improvement in the early phase of myocardial infarction (MI) is associated with a higher rate of late complications, including late-onset heart failure (LHF). The factors predicting LHF are not well understood. Our aims were to identify the factors predicting LHF and to determine the survival rate in these patients. Patients and method. The GISSI-Prevenzione trial involved 11 323 low-risk patients (NYHA class ≤ II) who had had a recent MI (<3 months). It was a multicenter, open-label, clinical trial of the efficacy of treatment with polyunsaturated fatty acids, vitamin E, both, or neither. Patients with heart failure at baseline and those whose ejection fraction was unknown (n = 2908) were excluded from the present analysis. Late-onset heart failure was defined prospectively as hospital admission due to heart failure. A Cox regression model adjusted for major covariates was used for risk analysis. Results. The study included 8415 patients. During 3.5 years of follow-up, 192 (2.3{\%}) developed LHF. The risk of LHF could be predicted from readily available parameters: age (per year; RR=1.07; 95{\%} CI, 1.05-1.09), ejection fraction (per 1{\%} increment; RR=0.96; 95{\%} CI, 0.94-0.97), heart rate (≥74 beats/min; RR=1.62; 95{\%} CI, 1.21-2.16), white blood cell count (≥8900 per ml; RR=1.42; 95{\%} CI, 1.05-1.94), diabetes (RR=1.62; 95{\%} CI, 1.17-2.24), hypertension (RR=1.76; 95{\%} CI, 1.33-2.34), peripheral artery disease (RR=2.1 1; 95{\%} CI, 1.32-3.37), and reinfarction (RR=2.09; 95{\%} CI, 1.28-3.39). LHF was associated with poor survival: (RR=2.34; 95{\%} CI, 1.63-3.36). Conclusions. The risk of LHF in post-MI patients can be predicted from readily available parameters. LHF was associated with a poor prognosis.",
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AU - Macchia, Alejandro

AU - Levantesi, Giacomo

AU - Marfisi, Rosa M.

AU - Franzosi, Maria G.

AU - Maggioni, Aldo P.

AU - Nicolosi, Gian L.

AU - Schweiger, Carlo

AU - Tavassi, Luigi

AU - Tognoni, Gianni

AU - Valagussa, Franco

AU - Marchioli, Roberto

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N2 - Introduction and objectives. Improvement in the early phase of myocardial infarction (MI) is associated with a higher rate of late complications, including late-onset heart failure (LHF). The factors predicting LHF are not well understood. Our aims were to identify the factors predicting LHF and to determine the survival rate in these patients. Patients and method. The GISSI-Prevenzione trial involved 11 323 low-risk patients (NYHA class ≤ II) who had had a recent MI (<3 months). It was a multicenter, open-label, clinical trial of the efficacy of treatment with polyunsaturated fatty acids, vitamin E, both, or neither. Patients with heart failure at baseline and those whose ejection fraction was unknown (n = 2908) were excluded from the present analysis. Late-onset heart failure was defined prospectively as hospital admission due to heart failure. A Cox regression model adjusted for major covariates was used for risk analysis. Results. The study included 8415 patients. During 3.5 years of follow-up, 192 (2.3%) developed LHF. The risk of LHF could be predicted from readily available parameters: age (per year; RR=1.07; 95% CI, 1.05-1.09), ejection fraction (per 1% increment; RR=0.96; 95% CI, 0.94-0.97), heart rate (≥74 beats/min; RR=1.62; 95% CI, 1.21-2.16), white blood cell count (≥8900 per ml; RR=1.42; 95% CI, 1.05-1.94), diabetes (RR=1.62; 95% CI, 1.17-2.24), hypertension (RR=1.76; 95% CI, 1.33-2.34), peripheral artery disease (RR=2.1 1; 95% CI, 1.32-3.37), and reinfarction (RR=2.09; 95% CI, 1.28-3.39). LHF was associated with poor survival: (RR=2.34; 95% CI, 1.63-3.36). Conclusions. The risk of LHF in post-MI patients can be predicted from readily available parameters. LHF was associated with a poor prognosis.

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KW - Heart failure

KW - Myocardial infarction

KW - Prognosis

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