Determinants of Oncogenic Transformation in Acute Promyelocytic Leukemia: The Hetero-Union Makes the Force

Research output: Contribution to journalArticlepeer-review

Abstract

Acute promyelocytic leukemia (APL) is caused by chromosomal translocations that involve the retinoic acid receptor α (RAR) and several other genes to yield X-RAR fusion proteins. Unlike wild-type RARs, which require heterodimerization with the retinoid X receptor (RXR) for their function as DNA-binding transcriptional regulators, X-RAR fusion proteins bind DNA and deregulate transcription as homo-oligomers. In this issue of Cancer Cell, however, Zeisig et al. and Zhu et al. show that RXR recruitment is a critical determinant for the transforming potential of oligomeric X-RAR fusion proteins and explore the possibility for targeted interventions in APL with either RAR or RXR ligands.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalCancer Cell
Volume12
Issue number1
DOIs
Publication statusPublished - Jul 10 2007

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

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