Determinants of oxidative stress related to gender: Relevance of age and smoking habit

Cristina Vassalle, Cristina Novembrino, Silvia Maffei, Rosalia Sciarrino, Rachele De Giuseppe, Luisella Vigna, Federica De Liso, Antonella Mercuri, Fabrizia Bamonti

Research output: Contribution to journalArticlepeer-review


Background: Magnitude and major causes of oxidative stress may be different between sexes, although limitedly addressed in clinical studies with controversial results. The present study aimed to determine whether any gender-related difference exists concerning oxidative stress in a population of 332 subjects of both sexes, in a wide age range, with and without cigarette smoking habit. Methods: The Oxidative-INDEX was calculated after evaluation of serum hydroperoxides (ROMs) and total antioxidant capacity (OXY) by means of commercial kits (d-ROMs and Oxy-adsorbent Tests, Diacron, Italy) subtracting the OXY standardized variable from the ROMs standardized variable. Results: The Oxidative-INDEX resulted higher in women with respect to men (p

Original languageEnglish
Pages (from-to)1509-1513
Number of pages5
JournalClinical Chemistry and Laboratory Medicine
Issue number9
Publication statusPublished - Sep 1 2011


  • Age
  • Gender
  • Menopausal status
  • Oxidative stress
  • Smoking habit

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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