Determinants of patient and health care services delays for tuberculosis diagnosis in Italy: A cross-sectional observational study

Anna Maria Peri, Davide Paolo Bernasconi, Nadia Galizzi, Alberto Matteelli, Luigi Codecasa, Vincenza Giorgio, Antonio Di Biagio, Fabio Franzetti, Antonella Cingolani, Andrea Gori, Giuseppe Lapadula

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Prompt diagnosis of active tuberculosis (TB) has paramount importance to reduce TB morbidity and mortality and to prevent the spread of Mycobacterium tuberculosis. Few studies so far have assessed the diagnostic delay of TB and its risk factors in low-incidence countries. Methods: We present a cross-sectional multicentre observational study enrolling all consecutive patients diagnosed with TB in seven referral centres in Italy. Information on demographic and clinical characteristics, health-seeking trajectories and patients' knowledge and awareness of TB were collected. Diagnostic delay was assessed as patient-related (time between symptoms onset and presentation to care) and healthcare-related (time between presentation to care and TB diagnosis). Factors associated with patient-related and healthcare-related delays in the highest tertile were explored using uni- and multivariate logistic regression analyses. Results: We enrolled 137 patients, between June 2011 and May 2012. The median diagnostic delay was 66 days (Interquartile Range [IQR] 31-146). Patient-related and healthcare-related delay were 14.5 days (IQR 0-54) and 31 days (IQR: 7.25-85), respectively. Using multivariable analysis, patients living in Italy for < 5 years were more likely to have longer patient-related delay (> 3 weeks) than those living in Italy for > 5 years (Odds Ratio [OR] 3.47; 95% Confidence Interval [CI] 1.09-11.01). The most common self-reported reasons to delay presentation to care were the mild nature of symptoms (82%) and a good self-perceived health (76%). About a quarter (26%) of patients had wrong beliefs and little knowledge of TB, although this was not associated with longer diagnostic delay. Regarding healthcare-related delay, multivariate analysis showed that extra-pulmonary TB (OR 4.3; 95% CI 1.4-13.8) and first contact with general practitioner (OR 5.1; 95% CI 1.8-14.5) were both independently associated with higher risk of healthcare-related delay > 10 weeks. Conclusions: In this study, TB was diagnosed with a remarkable delay, mainly attributable to the healthcare services. Delay was higher in patients with extra-pulmonary disease and in those first assessed by general practitioners. We suggest the need to improve knowledge and raise awareness about TB not only in the general population but also among medical providers. Furthermore, specific programs to improve access to care should be designed for recent immigrants, at significantly high risk of patient-related delay. Trial registration: The study protocol was registered under the US National Institute of Health ClinicalTrials.gov register, reference number: NCT01390987. Study start date: June 2011.

Original languageEnglish
Article number690
JournalBMC Infectious Diseases
Volume18
Issue number1
DOIs
Publication statusPublished - Dec 20 2018

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Italy
Health Services
Observational Studies
Patient Care
Tuberculosis
Cross-Sectional Studies
Delivery of Health Care
Odds Ratio
Confidence Intervals
General Practitioners
Health
National Institutes of Health (U.S.)
Pulmonary Tuberculosis
Mycobacterium tuberculosis
Lung Diseases
Multicenter Studies
Referral and Consultation
Multivariate Analysis
Logistic Models
Regression Analysis

Keywords

  • Access to care
  • Diagnostic delay
  • Tuberculosis

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Peri, A. M., Bernasconi, D. P., Galizzi, N., Matteelli, A., Codecasa, L., Giorgio, V., ... Lapadula, G. (2018). Determinants of patient and health care services delays for tuberculosis diagnosis in Italy: A cross-sectional observational study. BMC Infectious Diseases, 18(1), [690]. https://doi.org/10.1186/s12879-018-3609-4

Determinants of patient and health care services delays for tuberculosis diagnosis in Italy : A cross-sectional observational study. / Peri, Anna Maria; Bernasconi, Davide Paolo; Galizzi, Nadia; Matteelli, Alberto; Codecasa, Luigi; Giorgio, Vincenza; Di Biagio, Antonio; Franzetti, Fabio; Cingolani, Antonella; Gori, Andrea; Lapadula, Giuseppe.

In: BMC Infectious Diseases, Vol. 18, No. 1, 690, 20.12.2018.

Research output: Contribution to journalArticle

Peri, AM, Bernasconi, DP, Galizzi, N, Matteelli, A, Codecasa, L, Giorgio, V, Di Biagio, A, Franzetti, F, Cingolani, A, Gori, A & Lapadula, G 2018, 'Determinants of patient and health care services delays for tuberculosis diagnosis in Italy: A cross-sectional observational study', BMC Infectious Diseases, vol. 18, no. 1, 690. https://doi.org/10.1186/s12879-018-3609-4
Peri, Anna Maria ; Bernasconi, Davide Paolo ; Galizzi, Nadia ; Matteelli, Alberto ; Codecasa, Luigi ; Giorgio, Vincenza ; Di Biagio, Antonio ; Franzetti, Fabio ; Cingolani, Antonella ; Gori, Andrea ; Lapadula, Giuseppe. / Determinants of patient and health care services delays for tuberculosis diagnosis in Italy : A cross-sectional observational study. In: BMC Infectious Diseases. 2018 ; Vol. 18, No. 1.
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AU - Peri, Anna Maria

AU - Bernasconi, Davide Paolo

AU - Galizzi, Nadia

AU - Matteelli, Alberto

AU - Codecasa, Luigi

AU - Giorgio, Vincenza

AU - Di Biagio, Antonio

AU - Franzetti, Fabio

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N2 - Background: Prompt diagnosis of active tuberculosis (TB) has paramount importance to reduce TB morbidity and mortality and to prevent the spread of Mycobacterium tuberculosis. Few studies so far have assessed the diagnostic delay of TB and its risk factors in low-incidence countries. Methods: We present a cross-sectional multicentre observational study enrolling all consecutive patients diagnosed with TB in seven referral centres in Italy. Information on demographic and clinical characteristics, health-seeking trajectories and patients' knowledge and awareness of TB were collected. Diagnostic delay was assessed as patient-related (time between symptoms onset and presentation to care) and healthcare-related (time between presentation to care and TB diagnosis). Factors associated with patient-related and healthcare-related delays in the highest tertile were explored using uni- and multivariate logistic regression analyses. Results: We enrolled 137 patients, between June 2011 and May 2012. The median diagnostic delay was 66 days (Interquartile Range [IQR] 31-146). Patient-related and healthcare-related delay were 14.5 days (IQR 0-54) and 31 days (IQR: 7.25-85), respectively. Using multivariable analysis, patients living in Italy for < 5 years were more likely to have longer patient-related delay (> 3 weeks) than those living in Italy for > 5 years (Odds Ratio [OR] 3.47; 95% Confidence Interval [CI] 1.09-11.01). The most common self-reported reasons to delay presentation to care were the mild nature of symptoms (82%) and a good self-perceived health (76%). About a quarter (26%) of patients had wrong beliefs and little knowledge of TB, although this was not associated with longer diagnostic delay. Regarding healthcare-related delay, multivariate analysis showed that extra-pulmonary TB (OR 4.3; 95% CI 1.4-13.8) and first contact with general practitioner (OR 5.1; 95% CI 1.8-14.5) were both independently associated with higher risk of healthcare-related delay > 10 weeks. Conclusions: In this study, TB was diagnosed with a remarkable delay, mainly attributable to the healthcare services. Delay was higher in patients with extra-pulmonary disease and in those first assessed by general practitioners. We suggest the need to improve knowledge and raise awareness about TB not only in the general population but also among medical providers. Furthermore, specific programs to improve access to care should be designed for recent immigrants, at significantly high risk of patient-related delay. Trial registration: The study protocol was registered under the US National Institute of Health ClinicalTrials.gov register, reference number: NCT01390987. Study start date: June 2011.

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KW - Access to care

KW - Diagnostic delay

KW - Tuberculosis

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