TY - JOUR
T1 - Determinants of physiologic 18F-FDG uptake in brown adipose tissue in sequential PET/CT examinations
AU - Pace, Leonardo
AU - Nicolai, Emanuele
AU - D'Amico, Domenico
AU - Ibello, Francesco
AU - Morte, Anna Maria Della
AU - Salvatore, Barbara
AU - Pizzuti, Laura Micol
AU - Salvatore, Marco
AU - Soricelli, Andrea
PY - 2011/10
Y1 - 2011/10
N2 - Purpose: The aim of this study was to assess independent predictors of 2-deoxy-2-[ 18F]fluoro-Dglucose ( 18F-FDG) uptake in brown adipose tissue (BAT) in patients undergoing repeated positron emission tomography (PET)/computed tomography (CT) scans. Procedures: Eight hundred forty-eight (mean age 50.9±16 years) patients in whom PET/CT scan was repeated (mean interval 5±1.5 months) constituted the study group. 18F-FDG uptake in characteristic areas of BAT, with CT density of adipose tissue, greater than background softtissue activity was considered as evidence of BAT uptake. Both distribution and maximum standardized uptake values (SUVmax) were registered. Clinical and anamnestic data were collected for each patient. Results: 18F-FDG uptake in BAT was present in 8.6% patients at first scan. Independent predictors of presence of uptake were age (younger), gender (female), body mass index (lower), andmaximum outdoor temperature (lower). Age was the only independent predictor of BAT 18F-FDG uptake distribution, while SUVmax was related to both age and outdoor temperature. Independent determinants of persistence of BAT 18F-FDG uptake at second PET/CT were outdoor temperature at time of second scan and extension of metabolically active BAT at first scan. Conclusions: Age, body mass index, and outdoor temperature are significant determinants of BAT evidence at 18F-FDG PET/CT. Moreover, extension of BAT and outdoor temperature are the strongest determinants of persistence of BAT evidence on 18F-FDG PET/CT in repeated scan.
AB - Purpose: The aim of this study was to assess independent predictors of 2-deoxy-2-[ 18F]fluoro-Dglucose ( 18F-FDG) uptake in brown adipose tissue (BAT) in patients undergoing repeated positron emission tomography (PET)/computed tomography (CT) scans. Procedures: Eight hundred forty-eight (mean age 50.9±16 years) patients in whom PET/CT scan was repeated (mean interval 5±1.5 months) constituted the study group. 18F-FDG uptake in characteristic areas of BAT, with CT density of adipose tissue, greater than background softtissue activity was considered as evidence of BAT uptake. Both distribution and maximum standardized uptake values (SUVmax) were registered. Clinical and anamnestic data were collected for each patient. Results: 18F-FDG uptake in BAT was present in 8.6% patients at first scan. Independent predictors of presence of uptake were age (younger), gender (female), body mass index (lower), andmaximum outdoor temperature (lower). Age was the only independent predictor of BAT 18F-FDG uptake distribution, while SUVmax was related to both age and outdoor temperature. Independent determinants of persistence of BAT 18F-FDG uptake at second PET/CT were outdoor temperature at time of second scan and extension of metabolically active BAT at first scan. Conclusions: Age, body mass index, and outdoor temperature are significant determinants of BAT evidence at 18F-FDG PET/CT. Moreover, extension of BAT and outdoor temperature are the strongest determinants of persistence of BAT evidence on 18F-FDG PET/CT in repeated scan.
KW - F-FDG
KW - Brown adipose tissue
KW - PET/CT
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U2 - 10.1007/s11307-010-0431-9
DO - 10.1007/s11307-010-0431-9
M3 - Article
C2 - 20852948
AN - SCOPUS:84855680761
VL - 13
SP - 1029
EP - 1035
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
SN - 1536-1632
IS - 5
ER -