Determinants of response to a cisplatin-based regimen as neoadjuvant chemotherapy in stage IB-IIB invasive cervical cancer

Giorgio Bolis, Iwona Van Zainten-Przybysz, Giovanna Scarfone, Flavia Zanaboni, Claudio Scarabelli, Saverio Tateo, Marcella Calabrese, Fabio Parazzini

Research output: Contribution to journalArticlepeer-review

Abstract

The response rate and the determinants of response to a cisplatin-based regimen of neodjuvant chemoterapy (NACT) in women with a histologically confirmed first-diagnosis of invasive bulky stage IB-IIB cervical cancer are analyzed. A total of 79 cases were treated with cisplatin (40 mg/m2) each 7 days for seven courses. During the first, fourth, and seventh cycles, ifosfamide (3.5 g/m2) was given by infusion for 24 hr. At the end of the seven cycles, 51 had a partial response (64.5%) and 4 a complete pathological response (5.1%). The overall 24-month cumulative survival was 80%, being 93% in responders and 43% in nonresponders (log-rank test, P <0.05). With respect to the 66 subjects for whom pretreatment status of pelvic lymph nodes was available, complete or partial response was obtained in 35 of 42 subjects with negative pelvic lymph nodes at computed tomography, but in only 13 of 24 with positive lymph nodes. The corresponding odds ratios of response was 0.2 for women with positive status in comparison with those with negative status (95% confidence interval, 0.1-0.4). With respect to the 66 women who underwent surgery after NACT, of the 24 women with pretreatment positive lymph nodal status, 15 had positive nodes at surgery, but in 9 eases the histological analysis of nodes showed negative findings. Positive nodes at surgery were observed in 2 of the 42 subjects with negative nodes before treatment.

Original languageEnglish
Pages (from-to)62-65
Number of pages4
JournalGynecologic Oncology
Volume63
Issue number1
DOIs
Publication statusPublished - Oct 1996

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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