Determinants of the severity of comorbid migraine in multiple sclerosis

Veronica Villani, Laura De Giglio, Giuliano Sette, Carlo Pozzilli, Marco Salvetti, Luca Prosperini

Research output: Contribution to journalArticlepeer-review


A high co-morbidity between multiple sclerosis (MS) and migraine has been reported, especially in young female patients affected by a relapsing-remitting (RR) course of MS. In this study, we aimed to elucidate the determinants of the severity of comorbid migraine in MS. Demographic, clinical and psychometric variables were collected from a cohort of 205 RR-MS patients regularly attending to an Italian outpatient MS Centre. Of them, 102 (49.8 %) were diagnosed as affected by comorbid migraine. About one-third of MS patients with comorbid migraine have asked the attending neurologist a specific anti-migraine treatment. Despite this, only few MS patients (10.8 %) reported a prior use of prophylactic drugs, and even fewer (2.9 %) took triptans as pain killers; these proportions were significantly lower when compared with those of a control group of 63 migraineurs subjects without MS (p

Original languageEnglish
Pages (from-to)1345-1353
Number of pages9
JournalNeurological Sciences
Issue number6
Publication statusPublished - Mar 23 2012


  • Comorbidity
  • Disability
  • Migraine
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)


Dive into the research topics of 'Determinants of the severity of comorbid migraine in multiple sclerosis'. Together they form a unique fingerprint.

Cite this